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Further structural analysis of GnRH complexes with metal ions.

Nakamura K, Kodaka M, El-Mehasseb I, Gajewska A, Okuno H, Ochwanowska E, Witek B, Kozłowski H, Kochman K.
Journal Article 2005; 26(3): 247-252 PubMed PMID: 15990730 Citation  Keywords:  Animals, Copper:chemistry, Gonadotropin-Releasing Hormone:chemistry, Metals, Heavy:chemistry, Nickel:chemistry, Nuclear Magnetic Resonance, Biomolecular, Protons, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization,.   

: MALDI-TOF mass spectrometry, 1H NMR spectrometry, the continuous variation method and molecular modeling by MM3 calculation confirmed our earlier studies showing that gonadotropin-releasing hormone (GnRH) forms complex with copper(II) ion with the binding ratio 1:1. The copper(II) complex formed at physiological pH has a square planar configuration and GnRH complexes with nickel(II) and cobalt(II) ions are less stable than that of copper(II)....

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