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Clinical Trial 2008; 29(1): 107-112 PubMed PMID: 18283256 Citation  Keywords:  Acromegaly:complications, Adenoma:etiology, Adult, Aged, Blood Glucose:metabolism, Colonic Polyps:etiology, Colorectal Neoplasms:etiology, Female, Growth Hormone:blood, Homeostasis:physiology, Humans, Hyperinsulinism:complications, Insulin:blood, Insulin .   

INTRODUCTION: Pathogenesis of colonic lesions in patients with acromegaly remains still unclear. There are suggestions that apart from somatotropin axis hormones (GH and IGF-1), other agents also take part in this process. Molecular and animal studies indicate a vital role of hyperinsulinemia in development of colorectal neoplasms.

AIM OF THE STUDY: To evaluate a relation between insulin level, insulin resistance and its anthropometric markers and colorectal lesions in patients with acromegaly.

MATERIAL AND METHODS: The study consisted of 40 patients with active, newly diagnosed acromegaly; 24 women and 16 men aged from 24 to 77 years (mean age 50.1, SD+/-12.1). The analysis included the results of somatotropin axis function (GH and IGF-1 level), carbohydrate metabolism assessment (fasting serum glucose and insulin levels, oral glucose tolerance test, HOMA-IR for insulin resistance), the results of anthropometric measurement (BMI, WHR) and colonoscopy.

RESULTS: Colon pathologies (60 polyps and 2 flat lesions) were discovered in 19 (47.5%) patients with acromegaly, 8 of them had multiple polyps. Hyperplastic polyps were revealed in 11 (27.5%), while adenomas in 8 (20%) acromegalics. Patients with colorectal lesions were found to have higher WHR then subjects with normal colon (p=0.033). Positive correlation between the number of hyperplastic polyps in the patients with multiple changes in the colon and IGF-1 (p=0.025), insulin level (p=0.005) and HOMA-IR (p=0.001) was found. Multiple adenomas correlated positively with insulin level (p=0.007), HOMA-IR (p=0.006) and BMI (p=0.015).

CONCLUSIONS: The study results show a relation between hyperinsulinemia, insulin resistance and colon pathologies in acromegaly. Fasting insulin level and HOMA-IR correlate positively with the number of hyperplastic polyps and adenomas in acromegalic patients with multiply colorectal lesions....

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Case Reports 2008; 29(1): 44-46 PubMed PMID: 18283253 Citation  Keywords:  Adrenergic beta-Antagonists:adverse effects, Amnesia, Transient Global:diagnosis, Humans, Male, Middle Aged, Migraine Disorders:drug therapy, Recurrence, Substance Withdrawal Syndrome, Vasomotor System:physiopathology, Vasospasm, Intracranial:complication.   

: The etiology of Transient Global Amnesia (TGA) is not yet clear. A small part of TGA has a familiar occurrence. We report a case of recurrent, long-lasting familiar amnesia occurring after betablocker treatment withdrawal in a migrainous patient. We suggest that familiar TGA could be caused by the mechanism of vasospasm rather than venous congestion and that the abnormal cerebral vasomotor control could be the hereditary substrate in this condition....

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Evaluation Studies 2008; 29(1): 151-158 PubMed PMID: 18283252 Citation  Keywords:  Adult, Aged, Aged, 80 and over, Female, Gait Disorders, Neurologic:classification, Humans, Hypokinesia:classification, Male, Middle Aged, Motor Activity:physiology, Muscle Rigidity:classification, Parkinson Disease:classification, Reproducibility of Resul.   

: The dimensionality and reliability of the Motor Section of the Unified Parkinson Disease Rating Scale (UPDRS III) was studied with non-parametric Mokken scale analysis. UPDRS measures were obtained on 147 patients with PD (96 men, 51 women, mean age 61, range 35-80 yrs). Mokken scale analysis revealed a four-dimensional structure of the UPDRS III. Left-sided bradykinesia and rigidity appeared to co-occur with axial signs, gait disturbance, and speech/hypomimia, whereas right-sided bradykinesia and rigidity formed a second scale. Two further small scales were found consisting of right- and left-sided tremor. Results from the scale analysis reveal that all four subscales are strong. The reliability of the two tremor scales is low because they only contain three and four items, respectively....

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Controlled Clinical Trial 2008; 29(1): 168-172 PubMed PMID: 18283250 Citation  Keywords:  Adult, Affect:physiology, Anorexia Nervosa:physiopathology, Appetite:physiology, Body Temperature:physiology, Bulimia Nervosa:physiopathology, Circadian Rhythm:physiology, Eating:physiology, Female, Humans, Hunger:physiology, Phototherapy:methods,.   

OBJECTIVES: Light and food are important synchronizers of circadian rhythmicity. In eating disorders, the circadian rhythms of food intake and temperature are abnormal.

METHODS: We analyzed the effect of the morning light application on the circadian rhythm of tympanic temperature and its association with hunger and mood changes in the sample of 25 female patients hospitalized with DSM-IV diagnosis of eating disorders (14 bulimia nervosa and 11 anorexia nervosa) and in 6 healthy women.

RESULTS: Light therapy reduced interindividual variability of the temperature acrophase, synchronized the temperature and hunger rhythms and showed an antidepressant effect on patients with eating disorders. Bright light therapy normalized the circadian rhythm of body temperature in both anorexic and bulimic patients: phase advanced rhythm was delayed and phase delayed rhythm was advanced. In contrast with anorexic patients, the majority of bulimic patients had normal temperature rhythm before the therapy and this rhythm was not changed by the therapy.

CONCLUSION: The light therapy normalized temperature circadian rhythm in patient with eating disorders. We hypothesize that the light therapy can also contribute to improvement of pathological eating pattern because of the functional connections between light and food entrained oscillators. The light may help to restore the irregular circadian rhythmicity induced by chaotic food intake....

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Journal Article 2008; 29(1): 137-140 PubMed PMID: 18283245 Citation  Keywords:  Adult, Blood Glucose:metabolism, Female, Humans, Hypothyroidism:blood, Insulin:blood, Middle Aged, Severity of Illness Index, Thyroid Gland:physiopathology, Thyroidectomy, Thyrotropin:blood, Thyroxine:blood, Triiodothyronine:blood,.   

OBJECTIVES: Among the peripheral effects of thyroid hormone action, their influence on insulin is of great interest and conflicting data on this subject are available. Despite various studies already performed, of concern is whether insulin levels change in line with a deterioration of thyroid function. In this study, we investigated serum serum insulin levels and their correlations with thyroid-stimulating hormone (TSH), free thyroxine (FT4) and free triiodothyronine (FT3) in hypothyroid women.

DESIGN AND METHODS: Study group consisted of 22 women with a history of total thyroidectomy and radioiodine ablation performed for thyroid cancer, without diabetes or glucose intolerance. After six-weeks of thyroxine withdrawal, subjects were admitted to the Department of Endocrinology of the Poznan University of Medical Sciences to perform this study.

RESULTS: Plasma glucose and insulin were respectively: 4.76+/-0.47 mmol/L and 7.19+/-4.22 microU/mL. Serum TSH, FT4 and FT3 were respectively: 91.66+/-58.59 microU/mL, 2.65+/-2.19 pmol/L, and 1.53+/-1.00 pmol/L. Correlations were: r of -0. 4381 and P of 0.0414, r of -0.2368 and P of 0.2887, and r of 0.3954 and P of 0.0686 for insulin and FT4, insulin and FT3, and insulin and TSH, respectively. The only significant correlation was an inverse correlation between insulin and FT4.

CONCLUSIONS: In profound hypothyroidism insulin concentrations correlate with FT4 only, but not with FT3 or TSH....

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Journal Article 2008; 29(1): 125-130 PubMed PMID: 18283243 Citation  Keywords:  Back Pain:diagnosis, Humans, Lumbar Vertebrae, Muscle Strength Dynamometer, Muscle, Skeletal:physiopathology, Software, User-Computer Interface,.   

: Information regarding two versions of an instrument called a muscle dynamometer, which enables detailed information about muscle activity in the deep stabilisation spinal system (DSSS), presented in this article. The MD01 (muscle dynamometer ver. 01) is a simple electromechanical instrument that allows measurement of muscle activity in two areas of the lumbar spine region. Measurements on patients have confirmed the usefulness of quantifying the initial state of a patient before rehabilitation as well as monitoring rehabilitation treatment; the MD01 is a suitable device for obtaining these measurements. However, a new and improved version of the MD01, the MD02, has been developed. The MD02 allows measurements in four different body regions and now has a PC interface, which allows achieving of patient information and data export for use with statistical software....

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Journal Article 2008; 29(1): 87-90 PubMed PMID: 18283242 Citation  Keywords:  Animals, Circadian Rhythm:physiology, Female, Fetal Development:physiology, Fetal Weight:physiology, Models, Animal, Organ Size, Photoperiod, Placenta:pathology, Placentation:physiology, Pregnancy, Random Allocation, Rats, Rats, Wistar,.   

OBJECTIVE: To investigate the effect of circadian rhythm changes on fetal-placental development in pregnant rats.

MATERIAL AND METHOD: Pregnant rats were randomly allocated to 4 groups with 10 rats in each group. Group 1: 12 hours light 12 hours dark period (n:10, Control Group); Group 2: 6 hours light 6 hours dark period (n:10); Group 3: constant light group (n:10); Group 4: constant dark group (n:10). Rats were made to deliver by cesarean birth at the end of their pregnancy and their placenta, number and weight of the offspring, and placental histopathological changes were examined.

FINDING: Fetal number in the constant dark group was found significant in comparison to constant light group (p<0.01). Fetal weight in all groups with altered circadian rhythm was significantly lower than that in the control group (p<0.01). The decrease in fetal weight was more evident in the constant light group than in the constant dark group (p<0.01). Comparison of the histopathological findings of the placenta showed that placental edema, fibrin accumulation and leukocyte infiltration were significantly higher in constant light and constant dark groups than in other groups (p<0.01).

CONCLUSION: Circadian rhythm change in pregnancy adversely affects the fetal-placental development. More detailed studies are needed to clarify this mechanism....

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Journal Article 2008; 29(1): 173-177 PubMed PMID: 18283241 Citation  Keywords:  Animals, Boron:pharmacology, Female, Lactates:blood, Leptin:blood, Ovariectomy, Physical Conditioning, Animal:physiology, Rats, Rats, Sprague-Dawley, Swimming:physiology, Trace Elements:pharmacology,.   

OBJECTIVES: The aim of this study was to investigate the effects of intraperitoneal (IP) boron administration on leptin and lactate levels in swimming exercise in ovariectomized rats.

METHODS: Eighty adult female rats were equally allocated into 8 groups. Group 1; Control, Group 2; exercise control, Group 3; ovariectomized control, Group 4; Boron control (2 mg/kg/day), Group 5; ovariectomized plus exercise, Group 6; exercise plus IP boron, Group 7; ovariectomized and exercise group plus IP boron, Group 8; ovariectomized plus boron.

RESULTS: Leptin levels in Group 1 were higher than those in Groups 2, 3 and 4 and lower than those in groups 5, 6, 7 and 8 (p<0.01). Leptin levels were higher in Group 3 than in Groups 2 and 4 and significantly lower than in all other groups (p<0.01). Lactate levels in Groups 2 and 4 were higher than those in all other groups (p<0.01). Lactate levels were significantly lower in Groups 1, 3, 5 and 8 than in all other groups (p<0.01). Lactate levels in Groups 6 and 7 were significantly lower than those in Groups 2 and 4 (p<0.01) and higher than those in groups 1, 3 and 5 (p<0.01).

CONCLUSION: The present findings demonstrate that ovariectomy and acute swimming exercise in rats led to a significant decrease in leptin levels and a significant increase in lactate levels and that boron administration prevented the increased in circulating lactate concentration induced by swimming exercise....

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