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Journal Article 2007; 28(Suppl 4): 1-3 PubMed PMID: 18030258 Citation  Keywords:  Animals, Anti-Infective Agents:pharmacology, Cardiovascular System:drug effects, Central Nervous System:drug effects, Central Nervous System Depressants:adverse effects, Ethanol:adverse effects, Flavonoids:pharmacology, Gastrointestinal Tract:drug effects.   

: Moderate intake of wine may be protective against various neurologic, cardiovascular and gastroenteric diseases. Low concentration of alcohol (wine diluted with water 1:2 to 1:10) exhibits strong antimicrobial activity against majority of gastrointestinal pathogens as well as against Chlamydia pneumoniae. In contrast, higher doses of even diluted alcohol (more than 5-7 glasses a day) may cause severe neuropsychic disorders with major social consequences. Wine contains variety of molecules with cardioprotective effect and antiinfectious properties....

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Journal Article 2007; 28(Suppl 4): 10-11 PubMed PMID: 18030257 Citation  Keywords:  Aged:psychology, Alcohol Drinking:psychology, Cardiovascular System:drug effects, Central Nervous System Depressants:pharmacology, Cognition:drug effects, Ethanol:pharmacology, Humans, Neuropsychological Tests,.   

: The studies on the effect of moderate alcohol consumption on mental capacity in elderly and inflammatory markers in coronary heart disease are reviewed....

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Journal Article 2007; 28(Suppl 4): 11-14 PubMed PMID: 18030254 Citation  Keywords:  Blood Pressure:drug effects, Diastole, Dose-Response Relationship, Drug, Humans, Systole, Time Factors, Wine,.   

: Efficacy of varies wine sorts on blood pressure in 21 healthy individuals was prospectively studied. White wine Breslava most significantly decreased systolic blood pressure in comparison to wines from supermarket Veltlin or Frankovka (Blaufränkisch, Caberner Franc) (Raca). Decrease in diastolic blood pressure is similar in both white wines Breslava respectively Veltlin. In the second experiment during 8 hours blood pressure measurement, white wine Breslava from Nove Zamky region more significantly decreased systolic blood pressure in comparison to Low Carpathian wines (region Raca). Both white wines significantly decreased diastolic blood pressure. Red wines from both regions did not have significant influence on systolic or diastolic blood pressure in doses of 1, 2 or 3 dcl....

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Journal Article 2007; 28(5): 565-573 PubMed PMID: 17984958 Citation  Keywords:  Adolescent, Adult, Age Factors, Androstenedione:blood, Autistic Disorder:blood, Case-Control Studies, Child, Dehydroepiandrosterone:blood, Female, Follicle Stimulating Hormone:blood, Hormones:therapeutic use, Humans, Leuprolide:therapeutic use, Male, Matc.   

: Impairments in social relatedness and communication, repetitive behaviors, abnormal movement patterns, and sensory dysfunction characterize autism spectrum disorders (ASDs). Seventy consecutive patients with an ASD diagnosis (DSM-IV criteria, >/= 6 years-old) who presented to the Genetic Centers of America for outpatient genetic/developmental evaluations from 2005-2007 were examined. Patients were evaluated using CLIA-approved Laboratory Cooperation of America (LabCorp) testing for: serum testosterone, serum free testosterone, % free testosterone, serum/plasma dehydroepiandrosterone (DHEA), androstendione, and follicle-stimulating hormone (FSH). Morning blood samples collected following an overnight fast, compared to the pertinent reference means, showed significantly increased relative mean levels for: serum testosterone (158%), serum free testosterone (214%), percent free testosterone (121%), DHEA (192%), and androstenedione (173%). By contrast, compared to the pertinent reference mean, the relative mean level of FSH (51%) was significantly decreased. Additionally, at least one of the androgen attributes examined exceeded its recognized laboratory age- and sex-specific reference range in 81.4% (57 of 70) of the patients examined. With respect to their age- and sex-specific reference ranges, females had significantly higher overall mean relative testosterone and relative free testosterone levels than males. Increased androgens in patients diagnosed with ASDs may involve cyclical interactions between the androgen and the transsulfuration pathways, particularly following mercury exposure. A review of therapies that have significantly improved clinical outcomes in ASD patients indicates they share commonality in helping lower androgens. Thus, androgens should be routinely clinically measured in patients with an ASD diagnosis and appropriate androgen-lowering therapies considered for those who have significantly elevated levels....

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Journal Article 2007; 28(5): 547-548 PubMed PMID: 17984957 Citation  Keywords:  Child, Preschool, Diagnosis, Differential, Hernia, Inguinal:diagnosis, Humans, Hypospadias:complications, Male, Ovotesticular Disorders of Sex Development:complications, Sex Determination Analysis, Treatment Outcome,.   

: This study examined the differential diagnosis of inguinoscrotal masses and true hermaphroditism as well as incarcerated inguinal hernia in the differential diagnosis of abnormal inguinoscrotal masses. Inguinoscrotal masses are a rare presentation of true hermaphroditism. A child with an inguinoscrotal mass of the right groin and penoscrotal hypospadias was diagnosed. Our case suggested that abnormal inguinoscrotal masses occur in true hermaphroditism as well as incarcerated inguinal hernia. These congenital anomalies should be considered in the differential diagnosis of inguinoscrotal masses of the groin....

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Journal Article 2007; 28(5): 652-658 PubMed PMID: 17984956 Citation  Keywords:  Animals, Arachnoid:microbiology, Brain:microbiology, Disease Models, Animal, Meninges:microbiology, Meningitis, Bacterial:microbiology, Pia Mater:microbiology, Random Allocation, Rats, Rats, Sprague-Dawley, Spinal Cord:microbiology, Staphylococcus aureus:.   

OBJECTIVE: To evaluate leptomeningeal and subpial inflammatory responses of experimental Staphylococcus aureus bacteriemia following intraperitoneal and intravenous applications and to compare the inflammatory reactions in different regions of central nervous system.

MATERIAL AND METHODS: Forty anesthetized rats were divided into four groups equal in number. The rats in group-I were given 1 ml suspension of Staphylococcus aureus intraperitoneally. Group-II was the control group of group I; it was administrated 1 ml 0.9% NaCl in water intraperitoneally. The rats in group-III were given the same amount of bacteria intravenously. Group IV was the control group of the group-III; it was administrated 1 ml 0.9% NaCl solution intravenously. The rats were sacrificed on the 21st day. Inflammatory changes of different regions of the central nervous system were examined under transmission electron microscopy. Statistical analysis was done by using variance analysis, Bonferroni, Tamhane post hoc, Student's t and univariate tests.

RESULTS: Thoracic and occipital regions were the most vulnerable zones. Increasing of collagen tissue was the most detected inflammatory change.

CONCLUSION: This experimental model can be used for inducing subpial and leptomeningeal inflammations and it may be developed for investigations of pathogenesis of leptomeningitis during systemic infections....

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Case Reports 2007; 28(5): 545-546 PubMed PMID: 17984955 Citation  Keywords:  Adolescent, Angelman Syndrome:complications, Child, Preschool, Chromosomes, Human, Pair 15:genetics, Humans, Hypothyroidism:blood, Immunoglobulins, Thyroid-Stimulating:blood, Sequence Deletion, Thyroxine:therapeutic use,.   

: Angelman Syndrome (AS, MIM 105830), classified among neurogenetic disorders, occurs with estimated frequency of 1:10 000 to 1:40 000. The characteristics features apart from neurodevelopmental impairment and seizures include peculiar face traits, absent speech, outburst of laughter, ataxia, stereotyped jerky (puppet-like) movements. The authors report three children with Angelman syndrome who were also diagnosed with hypothyroidism....

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Journal Article 2007; 28(5): 713-716 PubMed PMID: 17984953 Citation  Keywords:  Blood Flow Velocity, Female, Fetal Heart:physiology, Fetus:blood supply, Gestational Age, Humans, Pregnancy, Reference Values, Regional Blood Flow, Ultrasonography, Doppler, Pulsed, Ultrasonography, Prenatal:methods, Umbilical Veins:diagnostic imaging, Ve.   

UNLABELLED: The ductus venosus is the very important part of fetal venous circulation. It plays a central role in return of venous blood from the placenta. This unique shunt carries well-oxygenated blood from the umbilical vein through the inferior atrial inlet on its way across the foramen ovale. Using Doppler ultrasound, it is possible to assess the blood flow in fetal vessels including ductus venosus. It is observed, in animal and human studies, that the typical waveform for blood flow in ductus venosus in early pregnancy can be different depending on numerous conditions e.g. fetal karyotype. This study is performed to assess the physiologic parameters of blood flow in ductus venosus in uncomplicated early pregnancy.

MATERIAL AND METHODS: 404 women were examined between 11+0 and 13+6 weeks (+ days) of gestation by ultrasound. Fetal crown-rump length (CRL) was measured to assess the gestational age. The assessment of risk of fetal abnormalities was based on nuchal translucency (NT) measurement. The ductus venosus blood flow with color and spectral Doppler was obtained in all patients. The following features were assessed: pulsatility index (PI), and direction of flow (positive/negative) during atrial contraction (wave A). All cases were followed up to 22 weeks of gestation when the control scan was performed.

RESULTS AND CONCLUSIONS: 30 cases were excluded from the uncomplicated group due to: high risk of fetal abnormalities, fetal loss, confirmed fetal abnormalities and utero-placental pathology. 374 women were considered as uncomplicated pregnancy. In both uncomplicated and complicated groups the mean values for pulsatility index (PI) were established. The mean PI value in uncomplicated pregnancies was: 0.91 (SD +/- 0.32). No significant differences between groups were noticed. In 370 cases of uncomplicated pregnancy the A wave direction was positive but in 1.1% of cases the reverse flow in atrial contraction was observed....

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