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Lipofuscin, homocysteine and tissue polypeptide specific antigen in gestational hypertension.

Partyka R, Chmiel B, Sikora J, Grabowska T, Wróbel B, Praisner A, Pióro A, Jałowieicki P, Kokocinska D.
Journal Article 2007; 28(3): 311-314 PubMed PMID: 17627268 Citation  Keywords:  Blood Pressure, Creatinine:blood, Female, Homocysteine:blood, Humans, Hypertension, Pregnancy-Induced:blood, Lipofuscin:blood, Oxidative Stress, Peptides:blood, Pregnancy,.   

OBJECTIVE: The aim of this study were to assess the levels of lipofuscin (parameter of oxidative stress), homocysteine (as a marker of vascular injury) and tissue specific antigen - TPS - (as a marker of cell proliferation) in relation to arterial pressure of pregnant woman.

STUDY DESIGN: Healthy pregnant women (n=18), women with mild 140/90=< RR<160/100 (n=19), and severe 160/100=
RESULTS: Mean duration of gestation was 34+/-5 weeks, and there were no differences between groups. Serum lipofuscin levels in mild form of pregnancy-induced hypertension were decreased comparing to normal pregnancy. Homocysteine levels were decreased and TPS levels increased in both mild and severe gestational hypertension.

CONCLUSION: Our results suggest overestimation of the role of oxidative stress and hyperhomocysteinemia in gestational hypertension....

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