PURPOSE: Effect of organoselenium compound (selol), on antinociceptive action of opioid agonists in vincristine neuropathic pain model was investigated.
Bujalska M, Gumułka S. Effect of selenium compound (selol) on the opioid activity in vincristine induced hyperalgesia. Neuro Endocrinol Lett. 2008 Aug; 29(4): 552-557
OBJECTIVES: It is well known that colour exposure can influence emotions, behaviour and perception. To get further insight into these complex synesthetic phenomena, the effect of colour stimulation on auditory and somatosensory perception was systematically investigated.
Landgrebe M, Nyuyki K, Frank E, Steffens T, Hauser S, Eichhammer P, Hajak G, Langguth B. Effects of colour exposure on auditory and somatosensory perception--hints for cross-modal plasticity. Neuro Endocrinol Lett. 2008 Aug; 29(4): 518-521
OBJECTIVES: Body weight loss in patients with anorexia nervosa (AN) is accompanied by a number of hormonal and metabolic disorders. The scope and intensity of these disorders may have a considerable influence on the prognosis in this disease. The goal of the study was an evaluation of selected diagnostic examinations in comparison with clinical data of female patients with AN.
Nogal P, Pniewska-Siark B, Lewiński A. Evaluation of selected clinical and diagnostic parameters in girls with anorexia nervosa (I). Neuro Endocrinol Lett. 2008 Aug; 29(4): 421-427
OBJECTIVES: Previous studies in the female sheep have shown that photoperiod modulates the passage of sex steroids between the blood and the cerebrospinal fluid (CSF) and have suggested the involvement of efflux transport. The objective of the present work was to assess the presence of P-glycoprotein (Pgp), which could be responsible for this transport at the level of the choroid plexuses (CP).
Bougoin S, Lomet D, Kerboeuf D, Le Vern Y, Malpaux B, Thiery J. Evidence that the choroids plexus in female sheep express P-glycoprotein. Neuro Endocrinol Lett. 2008 Aug; 29(4): 438-442
OBJECTIVES: 1.) Expand the scope of neuroendocrine applications of functional neuroimaging techniques. 2.) Compare the covariance of amygdalar activity with that of the rest of the brain during pre- and post-menopausal levels of estrogen (E2). Based on the distribution of cortical E2 receptors and the neocortical regions where E2 has been shown to preferentially accumulate, we predict that E2 infusion will increase covariance of amygdalar activity with that of the temporal and frontal cortices.
Ottowitz W, Derro D, Dougherty D, Lindquist M, Fischman A, Hall J. FDG-PET analysis of amygdalar-cortical network covariance during pre- versus post-menopausal estrogen levels: potential relevance to resting state networks, mood, and cognition. Neuro Endocrinol Lett. 2008 Aug; 29(4): 467-474
: Alzheimer's disease (AD) is a serious neurodegenerative disease of aging. Recent projections of the dramatic increase in AD incidence worldwide by 2050 reveal its magnitude as a world-wide health crisis and underscore the urgent need to understand the etiology of AD in order to develop therapeutic interventions. A popular debate among scientists has traditionally pitted those in support of Beta amyloid protein as a causative factor ("Baptists") against others who implicate tau hyperphosphorylation ("Tauists"). Considering the significance of Beta amyloid protein and hyperphosphorlyated tau protein aggregates in AD pathology, this article delves into the nature of inflammation associated with these aggregates. Aspects of inflammation focus on microglia, resident immune cells of the CNS that are activated during AD inflammation and are known to play a significant role in pathogenesis. This article discusses the role of microglia, inflammation, and the immune response as a middle ground in the debate between the "Tauists" and the "Baptists" respective positions. It explores recent advances in immunotherapy and supports continued research in and use of immunosuppressive regimens as potential therapeutic interventions for AD....
Dhawan N, Puangco J, Jandial R. In search of a treatment for Alzheimer's disease and potential immunonosuppresive therapeutic interventions. Neuro Endocrinol Lett. 2008 Aug; 29(4): 410-420
: A synthetic analogue of a mother-hen odour named MHUSA (Mother Hen Uropygial Secretion Analogue) reduces stress-related behaviour in the chicken. We hypothesize that MHUSA may have an attractant effect on chicks. In order to test this, 30 chicks were individually exposed to MHUSA, placebo or neutral when self isolated in a straight shuttle box. The location of the chicks within the test chamber was recorded with 360 consecutive scan-sampled images. During the first three minutes immediately after introduction to the test area chicks spent more time in the neutral zone (p<0.05). However, taking the results from the total observation period, chicks spent more time in the MHUSA and placebo zones combined than in the neutral zone (p=0.07). They were more often observed in the MHUSA zone compared to the placebo zone (p<0.05). These results suggest that during the first three minutes in the shuttle, individuals were adapting to their new environment. After this period, chicks directed themselves towards specific local stimuli, as they tried to reach their group or something that resembled it. After a stressor was introduced, we observed a return to the same situation as during the first three minutes of the test, with chicks returning to the neutral zone, suggesting that the chick had its confidence in the environment. Three main conclusions may be drawn. Firstly, MHUSA has an attractant effect on naïve chicks. Secondly, it appears to play a role in the reaction of chicks faced with a stressful event, and finally, the reaction to MHUSA seems innate and does not require previous experience....
Madec I, Gabarrou J, Pageat P. Influence of a maternal odorant on copying strategies in chicks facing isolation and novelty during a standardized test. Neuro Endocrinol Lett. 2008 Aug; 29(4): 507-511
: Ten years old patient with juvenile form of metachromatic leukodystrophy (MDL) is presented. Apart from standard magnetic resonance (MR) protocol, the diffusion weighted sequence was performed and apparent diffusion coefficient (ADC) map was constructed. The cause of restricted diffusion is considered to be the deposits of metachromatic substance in the intercellular space, apparently similar reason for decrease of speed of diffusion in other storage diseases....
Seidl Z, Vaneckova M, Vitak T. Metachromatic leukodystrophy: magnetic resonance imaging (diffusion weighted image--DWI). Neuro Endocrinol Lett. 2008 Aug; 29(4): 428-430