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Journal Article 2014; 35(3): 198-201 PubMed PMID: 24977967 Citation  Keywords:  Analgesics:therapeutic use, Animals, Cannabis, Drug Resistance:drug effects, Endocannabinoids:deficiency, Fatigue Syndrome, Chronic:drug therapy, Fibromyalgia:drug therapy, Humans, Irritable Bowel Syndrome:drug therapy, Lipid Metabolism, Inborn Errors:com.   

OBJECTIVES: Ethan B. Russo's paper of December 1, 2003 explored the concept of a clinical endocannabinoid deficiency (CECD) underlying the pathophysiology of migraine, fibromyalgia, irritable bowel syndrome and other functional conditions alleviated by clinical cannabis.r />r /> METHODS: Available literature was reviewed, including searches via the National Library of medicine database and other sources.r />r /> RESULTS: A review of the literature indicates that significant progress has been made since Dr. Ethan B. Russo's landmark paper, just ten years ago (February 2, 2004). Investigation at that time suggested that cannabinoids can block spinal, peripheral and gastrointestional mechanisms that promote pain in headache, fibromyalgia, irritable bowel syndrome and muscle spasm.r />r /> CONCLUSION: Subsequent research has confirmed that underlying endocannabinoid deficiencies indeed play a role in migraine, fibromyalgia, irritable bowel syndrome and a growing list of other medical conditions. Clinical experience is bearing this out. Further research and especially, clinical trials will further demonstrate the usefulness of medical cannabis. As legal barriers fall and scientific bias fades this will become more apparent....

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Journal Article 2014; 35(3): 186-197 PubMed PMID: 24977966 Citation  Keywords:  Disorders of Excessive Somnolence:drug therapy, Drug Therapy:trends, Humans, Hypnotics and Sedatives:therapeutic use, Movement Disorders:drug therapy, Sleep Apnea Syndromes:drug therapy, Sleep Disorders, Circadian Rhythm:drug therapy, Sleep Initiation and.   

: Sleep disorders are frequent and disturbing, mostly chronic conditions. Despite the fact practice of sleep medicine is a young field. Sleep disorders were reduced to insomnia and even insomnia was not well studied until 1960ies. This article maps amazing development of sleep disorders treatment from the beginning till current date. The text covers both scientific and clinical perspectives on most frequent sleep related disorders including insomnias, hypersomnias, parasomnias, sleep related movement and breathing disorders, restless legs syndrome and circadian rhythm sleep disorders....

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Case Reports 2014; 35(3): 183-185 PubMed PMID: 24977965 Citation  Keywords:  Adult, Amines:therapeutic use, Anticonvulsants:adverse effects, Carbamazepine:adverse effects, Cyclohexanecarboxylic Acids:therapeutic use, Female, Humans, Hypothyroidism:chemically induced, Thyroxine:therapeutic use, Trigeminal Neuralgia:complications, V.   

: The question whether antiepileptic drugs alter thyroid function requires a better understanding. In our article, we report two sisters, one of whom was treated with levothyroxine because of hypothyroidism. Although both women received anticonvulsant therapy, transient hypothyroidism was observed only in the hypothyroid woman and was found after treatment with classic anticonvulsant agents (carbamazepine and sodium valproate) but not with gabapentin. Our report shows that the effect of anti-epileptic drugs on the thyroid gland depends on the patient's hormonal status and on the drug being used....

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Case Reports 2014; 35(3): 179-182 PubMed PMID: 24977964 Citation  Keywords:  Adult, Anti-Inflammatory Agents, Non-Steroidal:therapeutic use, Bromocriptine:therapeutic use, Female, Humans, Pituitary Neoplasms:drug therapy, Polyendocrinopathies, Autoimmune:drug therapy, Prolactinoma:drug therapy,.   

: Excessive prolactin release and/or receptor action may be implicated in the pathogenesis of many autoimmune disorders. We report here a case of a woman who developed Graves' disease and subclinical autoimmune adrenal failure, and was diagnosed as having autoimmune polyglandular syndrome type 2. Because of coexisting microprolactinoma she was treated with bromocriptine for 24 months. This treatment resulted in a normalization of thyroid and adrenal function tests (with the exception of 21-hydroxylase antibodies) and reduced monocyte cytokine release. Our study indicates that bromocriptine and probably also the remaining prolactin-lowering agents produce anti-inflammatory effects and may prevent or delay the progression of autoimmune disorders of endocrine glands....

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Case Reports 2014; 35(3): 175-178 PubMed PMID: 24977963 Citation  Keywords:  Administration, Oral, Adult, Female, Hormone Antagonists:administration & dosage, Humans, Leiomyoma:complications, Menstruation Disturbances:drug therapy, Middle Aged, Norpregnadienes:administration & dosage, Receptors, Progesterone:metabolism, Treatment .   

OBJECTIVES: Uterine fibroids are the most common benign tumors in women of reproductive age. Evidence suggest that ovarian steroid hormones, in particular, progesterone play a major role in promoting leiomyoma development and growth. For the last years there was an extensive research on selective progesterone receptor modulators and their use in therapy. Ulipristal acetate (UPA) is one of these modulators. The aim of this paper is to evaluate efficacy and safety of oral ulipristal acetate for the treatment in women with symptomatic uterine fibroids.r />r /> METHODS: The study group comprised five patients with uterine fibroids. All patients received 5 mg of ulipristal acetate per day for three months.r />r /> RESULTS: The total volume of fibroids decreased by 33-68%. In all patients during the administration of UPA significant reduction of menstrual bleeding was observed. Increase of endometrial thickness without clinical significance was observed in two patients. No significant side-effects were observed during the treatment period.r />r /> CONCLUSIONS: 1) The volume offibroids decreased from 33 to 68%. 2) The UPA administration effectively controlled excessive bleeding. 3) Treatment with UPA may modify the scope of the surgery. 4) UPA is a well-tolerated drug....

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Case Reports 2014; 35(3): 171-174 PubMed PMID: 24977962 Citation  Keywords:  Acromegaly:diagnosis, Adenoma, Acidophil:complications, Aged, Diabetes Mellitus:diagnosis, Female, Humans, Hyperthyroidism:complications, Magnetic Resonance Imaging, Pituitary Neoplasms:complications,.   

: A 66-year-old woman with acromegaly and diabetes mellitus as well as primary hyperthyroidism is described. Serum GH Levels were inappprpriately high.MRI revealed an enlarged sella turcica with intrasellar mass. Her HbAlc was 12.2% and fasting blood glucose 8.89 mmol/l. Thyroid hormone levels in serum and thyroidal radioiodine uptake values were elevated, while TSH measurements in serum were low. Anti TPO antibodies were negative, TSH receptor antibodies were normal. Thyrotoxicosis as the first presenting illness in acromegaly was particulary uncommon. An ultrasound thyroid scan showed a multinodular goiter. Histology of the pituitary lesion showed a typical eosinophilic adenoma which only secreted GH when tested with specific immunostain. Post-operatively, the patient's clinical conditions improved, however, secondary hypoadrenalism appeared....

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Case Reports 2014; 35(2): 98-103 PubMed PMID: 24878982 Citation  Keywords:  Abdominoplasty:methods, Adenocarcinoma:complications, Female, Gynecologic Surgical Procedures:methods, Humans, Leiomyoma:complications, Middle Aged, Obesity, Morbid:complications, Uterine Neoplasms:complications,.   

: Panniculectomy is a surgical procedure that involves removal of the skin and fat excess which facilitates access to the peritoneal cavity. In the paper we present three cases of morbidly obese women (BMI: 46.3-59.5) who were treated in the Department of Gynecology and Oncological Gynecology in Lodz. One of the patients underwent an operation due to the presence of a large cervical myoma. Two another women were treated for endometrial cancer. During all of the three procedures panniculectomy was the first stage of the operation....

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Journal Article 2014; 35(2): 154-158 PubMed PMID: 24878981 Citation  Keywords:  Adrenomedullin:blood, Aged, Antihypertensive Agents:therapeutic use, Calcitonin Gene-Related Peptide:blood, Cardiovascular Diseases:diagnosis, Case-Control Studies, Diabetes Mellitus, Type 2:blood, Dyslipidemias:complications, Female, Humans, Hypertension.   

OBJECTIVES: To evaluate the significance of plasma adrenomedullin and calcitonin gene-related peptide (CGRP) concentration in patients with Type 2 diabetes mellitus who are treated for hypertension and dyslipidemia.r />r /> METHOD: Plasma adrenomedullin and CGRP concentration, transthoracal echocardiography and ABPM were evaluated in 82 patients with Type 2 diabetes mellitus and 41 control subjects with no previous cardiovascular disease. All the subjects had casual blood pressure ≤140/90 mmHg or received antihypertensive medication, were treated by statin if LDL cholesterol was≥3mmol/L, by fibrates if triacylglyceroles≥2 mmol/L.r />r /> RESULTS: The mean age was 61±6 in patients with diabetes mellitus and 61±5 years in control subjects (p=0.9). Plasma CGRP was 3.0±1.8 in patients with diabetes mellitus and 2.3±1.0 ng/ml in control subjects (p=0.09). Plasma adrenomedullin was 2.2±0.9 in patients with diabetes mellitus and 2.8±1.1 ng/ml in control subjects (p=0.01). In patients with diabetes mellitus mass index of the left ventricle was significantly higher and the parameters of diastolic function were more deteriorated. Plasma adrenomedullin and CGRP correlated significantly negatively with serum creatinine and positively with mean 24 hours arterial blood pressure in patients with diabetes mellitus but not in control subjects. Plasma adrenomedullin concentration in patients with diabetes mellitus treated for hypertension was significantly reduced.r />r /> CONCLUSION: Despite concentration plasma adrenomedullin and CGRP modulation by cardioprotective treatment both neuropeptides remained involved in regulation of hemodynamic and metabolic parameters in patients with Type 2 diabetes mellitus. The low plasma of adrenomedullin in patients with Type 2 diabetic may be marker of the efficient intervention on cardiovascular risk factors....

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