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Ten years experience with 497 cases of neuroinfections in tropic: in limited laboratory infrastructure initially treat both, cerebral malaria and meningitis.

Benca J, Ondrusova A, Adamcova J, Takacova M, Polonova J, Taziarova M.
Journal Article 2007; 28(Suppl 2): 49-50 PubMed PMID: 17558383 Citation  Keywords:  Africa South of the Sahara:epidemiology, Anti-Bacterial Agents:therapeutic use, Antimalarials:therapeutic use, Artemisinins:therapeutic use, Ceftriaxone:therapeutic use, Chloramphenicol:therapeutic use, Diagnosis, Differential, Drug Therapy, Combination, .   

: Review of 497 cases of neuroinfections in 7 tropical clinics in Ethiopia, Uganda, Burundi, Kenya, Sudan within 2000-2007 was performed. 97.5% of all cases was cerebral malaria (40.1%) and bacterial meningitis (56.4%). TB meningitis, cerebral cryptococcosis and sleeping sickness were very rare....

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Infectious embolisation to the central nervous system from endocarditis: analyses of 99 cases.

Karvaj M, Krcmery V, Kalavsky E, Kisac P, Hricak V, Mlkvy P, Kovac M, Bauer F, Rudinsky B, Sramka M.
Journal Article 2007; 28(Suppl 2): 47-48 PubMed PMID: 17558382 Citation  Keywords:  Adolescent, Adult, Aged, Anti-Infective Agents:therapeutic use, Bacteremia:complications, Central Nervous System Diseases:etiology, Child, Child, Preschool, Cohort Studies, Endocarditis, Bacterial:complications, Enterococcus, Gram-Positive Bacterial Infec.   

: Within a cohort of 606 cases of infective endocarditis, 263 were complicated and 99 embolizing, of them 32 to the central nervous system (CNS). Significant predictors of CNS embolisation were inappropriate therapy (p<0.01) and enterococcal etiology (p<0.01). Mortality in patients with CNS emboli was 65% what was significantly higher than in cases without embolisation - 15% (p<0.01)....

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Cerebral malaria in children in South Sudan: 8 years experience in 261 cases.

Bartkovjak M, Ianetti R, Kutna K, Ondrusova A, Kniezova Z, Kalavsky M, Mykyta Y, Holeckova K, Vilmova M, Taziarova M, Benca J, Seckova S, Dubai A, Pivarnik M, Duris M, Bukovinova P, Kralova J, Ocenas M, Uhercik L, Bauer F, Huttova M, Kovac M, Shahum A.
Journal Article 2007; 28(Suppl 2): 45-46 PubMed PMID: 17558381 Citation  Keywords:  Antimalarials:therapeutic use, Artemisinins:therapeutic use, Child, Preschool, Clindamycin:therapeutic use, Coma:epidemiology, Comorbidity, Drug Therapy, Combination, Fever:epidemiology, Humans, Infant, Malaria, Cerebral:drug therapy, Quinine:therapeutic .   

: Two hundred-sixty-one (261) cases of cerebral malaria within last 8 years from 3 tropical clinics in South Sudan were analyzed. Coma was present at 79.8% and convulsions at 25.6%. However 90.5% of children were cured. Commonest antimalarial drugs used were intravenous quinine, clindamycin, artesunate and artemeter....

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Meningococcal meningitis among displaced and refugee camps in southern Sudan.

Benca J, Kralova J, Bukovinova P, Findova L, Bartkovjak M, Seckova S, Ondrusova A, Knieslova D, Njambi S.
Letter 2007; 28(Suppl 2): 45-46 PubMed PMID: 17558380 Citation  Keywords:  Anti-Bacterial Agents:therapeutic use, Ceftriaxone:therapeutic use, Child, Child, Preschool, Chloramphenicol:therapeutic use, Disease Notification, Humans, Meningitis, Meningococcal:drug therapy, Population Surveillance, Refugees, Sudan:epidemiology, Trea.   

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Infectious diseases in disaster areas/catastrophes.

Benca J, Kalavsky E, Miklosko J, Rudinsky B, Taziarova M, McKenzie F.
Journal Article 2007; 28(Suppl 2): 40-43 PubMed PMID: 17558379 Citation  Keywords:  Communicable Disease Control:methods, Communicable Diseases:epidemiology, Disaster Planning:methods, Disasters:classification, Disease Outbreaks:prevention & control, Humans, Terrorism, Warfare,.   

: There is very little data and no prospective research possible in the field of catastrophic medicine (disaster medicine) including infectious diseases. This minireview tries to contribute to the pathogenesis and outcome of infectious diseases in areas after anthropogenic (war, genocide, terrorist attack, industrial disasters) and non anthropogenic (natural) catastrophes (earthquake, floods, tsunamis, hurricanes, volcano eruptions). Therefore ISC received a proposal to create a working group on infectious diseases in areas after catastrophes, better to understand epidemiology, prevention and therapy of infectious diseases occurring in conjunction to various anthropogenic and non anthropogenic (natural) disasters....

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Neuroinfections and antimicrobials: do we need new molecules or new strategies?

Kalavsky E, Kisac P, Huttova M, Benca J, Krcmery V.
Journal Article 2007; 28(Suppl 2): 38-39 PubMed PMID: 17558378 Citation  Keywords:  Anti-Infective Agents:therapeutic use, Brain Diseases:drug therapy, Candidiasis:drug therapy, Cross Infection:drug therapy, Drug Resistance, Microbial, Fluconazole:therapeutic use, Humans, Meningitis:drug therapy, Pseudomonas Infections:drug therapy, Stap.   

: Within last 15 years, analyzing patterns of etiology and resistance in organisms causing neuroinfections, emergence of resistance has been observed in Slovakia in S. haemolyticus to teicoplanin (11%), Ps. aeruginosa and A. baumannii to meropenem (20%) and Candida spp. (non-albicans Candida spp.) to fluconazol (20%). There are no new antibiotics against carbapenem resistant Ps. aeruginosa and Acinetobacter baumannii....

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Neuroinfections complicating foreign body implants after perinatal trauma or meningitis in 60 children.

Rudinsky B, Bauer F, Kalavsky M, Huttova M, Sramka M, Kalavsky E, Benca J, Karvaj M, Jarcuska P, Liskova A, Kralinsky K, Ondrusova A, Taziarova M, Pevalova L, Kovac M, Miklosko J.
Journal Article 2007; 28(Suppl 2): 36-37 PubMed PMID: 17558377 Citation  Keywords:  Brain Injuries:complications, Cerebrospinal Fluid Shunts:adverse effects, Child, Child, Preschool, Foreign Bodies:microbiology, Humans, Hydrocephalus:complications, Infant, Infant, Newborn, Infant, Very Low Birth Weight, Intracranial Hemorrhages:complicat.   

: Meningitis after artificial implants in 60 children, mainly after foreign body infections (FBI) was caused more frequently by coagulase negative staphylococci and Ps. aeruginosa than other organisms and was significantly associated with perinatal trauma, hydrocephalus, haemorrhage or VLBW and had more neurologic sequels despite mortality was similar to other nosocomial meningitis....

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