Markers of nucleic acids and proteins oxidation among office workers exposed to air pollutants including (nano)TiO2 particles.
trong>OBJECTIVES:trong> Experimental studies using nanoscale TiO2 have documented lung injury, inflammation, oxidative stress, and genotoxicity. Human health data are extremely scarce.
trong>METHODS:trong> In exhaled breath condensate (EBC) and urine of 22 office employees occupationally exposed to TiO2 during their visit in the production workshops for average 14±9 min/day a panel of biomarkers of nucleic acids and proteins oxidation was studied, specifically 8-hydroxy-2-deoxyguanosine (8-OHdG), 8-hydroxyguanosine (8-OHG), 5-hydroxymethyl uracil (5-OHMeU), o-tyrosine (o-Tyr), 3-chlorotyrosine (3-ClTyr), and 3-nitrotyrosine (3-NOTyr). Examination was performed also in 14 comparable controls.
trong>RESULTS:trong> The median respirable TiO2 mass concentration in the workshops was 0.40 mg/m3, median number concentration was 2.32×104 particles/cm3 with 80% of the particles being
trong>CONCLUSION:trong> This pilot study suggests that even short nanoTiO2 exposure may lead to pulmonary oxidative stress; however this effect may be short-term and reversible. The clinical significance of these findings is unclear and more studies are needed.
Citation
Pelclova D, Zdimal V, Kacer P, Vlckova S, Fenclova Z, Navratil T, Komarc M, Schwarz J, Zikova N, Makes O, Zakharov S. Markers of nucleic acids and proteins oxidation among office workers exposed to air pollutants including (nano)TiO2 particles. Neuro Endocrinol Lett. 2016 Dec; 37(Suppl 1): 13-16