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Tetanic crisis and antiepileptic drugs. A case report.

Zdrojewicz Z, Dubiński A, Jonek A, Tomanek N, Krajewski W.
Case Reports 2005; 26(4): 317-319 PubMed PMID: 16136018 Citation  Keywords:  Adult, Anticonvulsants:adverse effects, Calcium:administration & dosage, Carbamazepine:adverse effects, Epilepsy, Tonic-Clonic:complications, Female, Humans, Hypocalcemia:chemically induced, Intellectual Disability:complications, Tetany:chemically induced.   

OBJECTIVE AND METHODS: We presented a rare case of tetanic crisis in a 23-year old mentally retarded woman with epilepsy after treatment by oxcarbazepine, the new anticonvulsant agent. We reviewed laboratory, radiographic and medical examinations and recommend a proper treatment in such cases.

RESULTS AND CONCLUSION: The laboratory tests revealed only severe hypocalcemia. We described the potential role of oxcarbazepine in the induction of activity of cytochrome P 450 system of hepar and increases of less active metabolism of vitamin D. Supplementation of vitamin D and calcium in patients taking antiepileptic drugs is in the same case crucial....

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