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Peptide Epitalon activates chromatin at the old age.

Khavinson V, Lezhava T, Monaselidze J, Jokhadze T, Dvalishvili N, Bablishvili N, Trofimova S.
Journal Article 2003; 24(5): 329-333 PubMed PMID: 14647006 Citation  Keywords:  Aged, Aging:physiology, Cells, Cultured, Euchromatin:drug effects, Heterochromatin:drug effects, Hot Temperature, Humans, Lymphocytes:cytology, Oligopeptides:pharmacology, Protein Denaturation, Ribosomal Proteins:genetics, Transcriptional Activation:drug .   

UNLABELLED: OBJECTIVES and design. We have studied the effect of synthetic peptide Epitalon on the activity of ribosomal genes, denaturation parameters of total heterochromatin, polymorphism of structural C-heterochromatin and the variability of facultative heterochromatin in cultured lymphocytes of persons aged 76-80 years.

RESULTS: The obtained data demonstrate that Epitalon induces the activation of ribosomal genes, decondensation of pericentromeric structural heterochromatin and the release of genes repressed due to the age-related condensation of euchromatic chromosome regions.

CONCLUSIONS: Epitalon has shown its ability to activate chromatin by modifying heterochromatin and heterochromatinized chromosome regions in the cells of older persons....

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