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Journal Article 2008; 29(2): 256-260 PubMed PMID: 18404143 Citation  Keywords:  Adolescent, Adult, Complement System Proteins:analysis, Female, Humans, Male, Middle Aged, Multiple Sclerosis:blood, Neuromyelitis Optica:blood, Thyroxine:blood, Triiodothyronine:blood,.   

OBJECTIVE: The aim of this study is to assess serum levels of thyroid hormones (TH) and complement C3, C4, CH50 in patients with multiple sclerosis (MS) and neuromyelitis optica (NMO), and investigate whether there is a correlation between serum TH and complement factors in these patients.

METHODS: One hundred and eighty-eight MS patients and sixty-five NMO patients were included in this study. The levels of serum TH were measured by magnetic antibody enzyme linking immunoassay and complement C3, C4 and CH50 were determined by immunoturbidimetry.

RESULTS: The levels of TT4, complement C4 and CH50 in the serum were significantly higher in NMO patients than that in the MS. There were no significant differences in serum TT3, FT3, FT4 concentrations between NMO and MS patient. In MS patients, significant correlations between mean EDSS levels and serum C3 (r=0.223, p=0.014), and serum C4 (r=0.216, p=0.017) were found, and serum TT3 was positively correlated with serum CH50 (r=0.342, p=0.01). In NMO patients, the positive association between serum FT4 and C4 (r=0.533, p=0.006) were also found.

CONCLUSIONS: These results indicate that NMO patients has different serum TH and complement C3, C4 and CH50 levels from MS patients, and that serum TH levels is correlated with CH50 and C4 in these patients, suggesting TH may play a different role in modulating the complement activation in MS and NMO....

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Journal Article 2008; 29(1): 131-136 PubMed PMID: 18283268 Citation  Keywords:  Adult, Case-Control Studies, Female, Humans, Hypothyroidism:blood, Middle Aged, Resistin:blood, Thyrotropin:blood, Thyroxine:blood, Triiodothyronine:blood,.   

OBJECTIVES: Although resistin is involved in metabolism, its role in humans is unclear. Since thyroid status influences metabolism, and since only few studies have evaluated the associations between resistin and thyroid status with inconclusive results, we investigated serum serum resistin levels and their correlations with TSH, FT4 and FT3 in hypothyroid and euthyroid women.

DESIGN AND METHODS: Study group consisted of 22 women with a history of total thyroidectomy and radioiodine ablation performed for thyroid cancer. Controls were 22 healthy euthyroid women matched for age and BMI. After six-weeks of thyroxine withdrawal, subjects were admitted to the Department of Endocrinology of the Poznan University of Medical Sciences to perform this study.

RESULTS: Serum resistin concentrations were lower in hypothyroid patients, 12.40 +/- 5.197 vs. 18.01 +/- 7.31, p=0.0065. In hypothyroid subjects, correlations were as follows: r of -0.2636 and p of 0.248, r of 0.0336 and p of 0.885, and r of 0.3080 and P of 0.174 for resistin and FT4, resistin and FT3, and resistin and TSH, respectively. In controls: r of 0.0311 and p of 0.8908, r of -0.0986 and p of 0.6625, and r of 0.1605 and p of 0.4754 for resistin and FT4, resistin and FT3, and resistin and TSH, respectively.

CONCLUSIONS: Short-term profound hypothyroidism decreased resistin levels. However, no significant correlations between the levels of circulating resistin and thyroid hormones and TSH were shown....

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Journal Article 2008; 29(1): 137-140 PubMed PMID: 18283245 Citation  Keywords:  Adult, Blood Glucose:metabolism, Female, Humans, Hypothyroidism:blood, Insulin:blood, Middle Aged, Severity of Illness Index, Thyroid Gland:physiopathology, Thyroidectomy, Thyrotropin:blood, Thyroxine:blood, Triiodothyronine:blood,.   

OBJECTIVES: Among the peripheral effects of thyroid hormone action, their influence on insulin is of great interest and conflicting data on this subject are available. Despite various studies already performed, of concern is whether insulin levels change in line with a deterioration of thyroid function. In this study, we investigated serum serum insulin levels and their correlations with thyroid-stimulating hormone (TSH), free thyroxine (FT4) and free triiodothyronine (FT3) in hypothyroid women.

DESIGN AND METHODS: Study group consisted of 22 women with a history of total thyroidectomy and radioiodine ablation performed for thyroid cancer, without diabetes or glucose intolerance. After six-weeks of thyroxine withdrawal, subjects were admitted to the Department of Endocrinology of the Poznan University of Medical Sciences to perform this study.

RESULTS: Plasma glucose and insulin were respectively: 4.76+/-0.47 mmol/L and 7.19+/-4.22 microU/mL. Serum TSH, FT4 and FT3 were respectively: 91.66+/-58.59 microU/mL, 2.65+/-2.19 pmol/L, and 1.53+/-1.00 pmol/L. Correlations were: r of -0. 4381 and P of 0.0414, r of -0.2368 and P of 0.2887, and r of 0.3954 and P of 0.0686 for insulin and FT4, insulin and FT3, and insulin and TSH, respectively. The only significant correlation was an inverse correlation between insulin and FT4.

CONCLUSIONS: In profound hypothyroidism insulin concentrations correlate with FT4 only, but not with FT3 or TSH....

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Journal Article 2007; 28(4): 367-381 PubMed PMID: 17693980 Citation  Keywords:  Aged, Case-Control Studies, Critical Illness:therapy, Female, Humans, Lipid Peroxidation:physiology, Male, Middle Aged, Oxidation-Reduction, Oxidative Stress:physiology, Regression Analysis, Treatment Outcome, Triiodothyronine:blood,.   

OBJECTIVES: Increased oxidative stress and low-T3 syndrome may develop in critically ill patients. The study aimed at evaluating the level of lipid peroxidation (LPO) in critically ill patients and at estimating the relationships among LPO level, the death rate, the rate of low-T3 syndrome and patient's clinical status.

METHODS: Lipid peroxidation (LPO) level was studied in seventy (70) adult, critically ill patients and 48 healthy volunteers. Critically ill patients were classified into survivors and non-survivors, or those with and without the low-T3 syndrome (normal-T3).

RESULTS: LPO level was four times higher in critically ill patients than in healthy volunteers. Among non-survivors, LPO level was higher in patients with the low-T3 syndrome than in patients without this syndrome, and among survivors, the tendency was opposite. Additionally, the extent, to which LPO level increased, depended on the kind of the disease. The degree of LPO variability was higher in survivors than in non-survivors. LPO level was lower in patients with higher number of therapeutic interventions.

CONCLUSION: A tremendous increase in oxidative damage to lipids in critically ill patients strongly depends on the kind of pathological process and, under certain conditions, higher LPO levels could be due to more favourable outcome....

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Journal Article 2007; 28(4): 417-421 PubMed PMID: 17693966 Citation  Keywords:  Adult, Body Mass Index, Case-Control Studies, Female, Humans, Hypothyroidism:blood, Leptin:blood, Middle Aged, Thyroid Gland:metabolism, Thyroidectomy:adverse effects, Thyrotropin:blood, Thyroxine:blood, Triiodothyronine:blood,.   

OBJECTIVES: Leptin regulates body weight by suppressing food intake and increasing energy expenditure. Alterations in thyroid hormone levels are also associated with changes in body weight but the effect of thyroid hormone deficiency on serum leptin in humans is unclear.

DESIGN AND METHODS: The aim of this study was to measure leptin levels and to investigate their associations with thyroid hormones in 22 women with severe hypothyroidism after total thyroidectomy, and in a group of 22 healthy euthyroid control female subjects matched for age and body mass index (BMI). Their plasma leptin, free thyroxine, triiodothyronine and TSH were measured.

RESULTS: Leptin levels in subjects and controls were (pg/mL) 18761.64+/-16973.96 and 18729.19+/-18014.05, respectively, p=0.9; leptin did not correlate with free thyroxine, triiodothyroinine and TSH: r=0.1039 and p=0.6453, r=0.0113 and p=0.9602, and r=-0.0525 and p=0.8165 for leptin and FT4, leptin and FT3, and leptin and TSH, respectively in subjects; r=-0.00056 and p=0.9980, r=0.248727 and p=0.2643, and r=-0.046919 and p=0.8357 for leptin and FT4, leptin and FT3, and leptin and TSH, respectively in controls. Leptin levels did not differ between subjects and controls and they did not correlate with thyroid hormones.

CONCLUSIONS: Leptin levels are not influenced by hypothyroidism and do not correlate with thyroid hormones in euthyroid and hypothyroid women....

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Journal Article 2006; 27(1-2): 247-252 PubMed PMID: 16648789 Citation  Keywords:  Adolescent, Adult, Exercise:physiology, Exercise Test, Humans, Testosterone:blood, Thyroid Hormones:blood, Thyrotropin:blood, Thyroxine:blood, Triiodothyronine:blood, Wrestling:physiology, Zinc:pharmacology,.   

OBJECTIVES: The present study aims to investigate how exhaustion exercise affects thyroid hormones and testosterone levels in elite athletes who are supplemented with oral zinc sulfate for 4 weeks.

METHODS: The study included 10 male wrestlers, who had been licensed wrestlers for at least 6 years. Mean age of the wrestlers who volunteered in the study was 18.70 +/- 2.4 years. All subjects were supplemented with oral zinc sulfate (3 mg/kg/day) for 4 weeks in addition to their normal diet. Thyroid hormone and testosterone levels of all subjects were determined as resting and exhaustion before and after zinc supplementation.

RESULTS: Resting TT3, TT4, FT3, FT4 and TSH levels of subjects were higher than the parameters measured after exhaustion exercise before zinc supplementation (p<0.05). Both resting and exhaustion TT3, TT4 and FT3 values after 4-week zinc supplementation were found significantly higher than both of the parameters (resting and exhaustion) measured before zinc supplementation (p<0.05). Resting total testosterone and free testosterone levels before zinc supplementation were significantly higher than exhaustion levels before zinc supplementation (p<0.05). Both resting and exhaustion total and free testosterone levels following 4-week zinc supplementation were found significantly higher than the levels (both resting and exhaustion) measured before zinc supplementation (p<0.05).

CONCLUSION: Findings of our study demonstrate that exhaustion exercise led to a significant inhibition of both thyroid hormones and testosterone concentrations, but that 4-week zinc supplementation prevented this inhibition in wrestlers. In conclusion, physiological doses of zinc administration may benefit performance....

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Clinical Trial 2005; 26(6): 830-834 PubMed PMID: 16380698 Citation  Keywords:  Adult, Analysis of Variance, Energy Metabolism:physiology, Exercise:physiology, Heart Rate:physiology, Humans, Male, Physical Exertion, Reference Values, Statistics, Nonparametric, Thyrotropin:blood, Thyroxine:blood, Triiodothyronine:blood,.   

BACKGROUND: Physical activity influences energy metabolism in human subjects by increasing activity-induced energy expenditure and resting metabolic rate for several hours after exercise. Effects of exercise on circulating thyroid hormone values remain controversial. We have investigated the effect of acute aerobic exercise on thyroid hormone values.

MATERIALS/METHODS: The effect of different intensity levels of acute aerobic exercise on thyroid hormones was investigated in 60 male well-trained athletes by performing bicycle ergometer at 45% (low intensity), 70% (moderate intensity), and 90% (high intensity). These intensities were selected according to their maximum heart rate (MHR). At each intensity level, heart rate, blood lactic acid, serum total thyroxine (T4), free thyroxine (fT4), total triiodothyronine (T3), free triiodothyronine (fT3) and thyroid stimulating hormone (TSH) values were measured.

RESULTS: The results of this study show that exercise performed at the anaerobic threshold (70% of maximum heart rate, lactate level 4.59 +/- 1.75 mmol/l) caused the most prominent changes in the amount of any hormone values. While the rate of T4, fT4, and TSH continued to rise at 90% of maximum heart rate, the rate of T3 and fT3 started to fall.

CONCLUSIONS: Maximal aerobic exercise greatly affects the level of circulating thyroid hormones....

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