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Journal Article 2007; 28(Suppl 4): 8-9 PubMed PMID: 18030256 Citation  Keywords:  Aged, Aged, 80 and over, Alcohol Drinking:epidemiology, Alcoholic Beverages, Coronary Disease:epidemiology, Databases, Factual, Humans, Hypertension:epidemiology, Longevity:drug effects, Slovakia:epidemiology, Surveys and Questionnaires, Wine,.   

: There was a significant difference in occurrence of coronary hearth disease and arterial hypertension occurrence in the sample of 16,345 patients living in northeast part of Slovak republic near Polish frontier versus to the viticulture regions of Nove Zamky, Sturovo in favour of villages in Bardejov region. Another difference was that 80 years and older respondents live significantly more frequently in south Slovakian viticulture villages....

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Journal Article 2007; 28(Suppl 4): 10-11 PubMed PMID: 18030255 Citation  Keywords:  Adult, Aged, Alcohol Drinking:epidemiology, Beer, Biomarkers:blood, Cross-Sectional Studies, Europe:epidemiology, Female, Humans, Inflammation:blood, Male, Middle Aged, Wine,.   

: Anti-inflammatory effects of moderate alcohol consumption have been proposed to explain why moderate alcohol intake lowers coronary heart disease risk. The relationship between overall alcohol, beer or wine consumption and markers of systemic inflammation in three different geographical areas in Europe, was investigated....

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Journal Article 2007; 28(Suppl 4): 11-14 PubMed PMID: 18030254 Citation  Keywords:  Blood Pressure:drug effects, Diastole, Dose-Response Relationship, Drug, Humans, Systole, Time Factors, Wine,.   

: Efficacy of varies wine sorts on blood pressure in 21 healthy individuals was prospectively studied. White wine Breslava most significantly decreased systolic blood pressure in comparison to wines from supermarket Veltlin or Frankovka (Blaufränkisch, Caberner Franc) (Raca). Decrease in diastolic blood pressure is similar in both white wines Breslava respectively Veltlin. In the second experiment during 8 hours blood pressure measurement, white wine Breslava from Nove Zamky region more significantly decreased systolic blood pressure in comparison to Low Carpathian wines (region Raca). Both white wines significantly decreased diastolic blood pressure. Red wines from both regions did not have significant influence on systolic or diastolic blood pressure in doses of 1, 2 or 3 dcl....

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Journal Article 2004; 25(3): 191-195 PubMed PMID: 15349084 Citation  Keywords:  Animals, Base Sequence, DNA Primers, Female, Gene Expression Regulation, Hypothalamus:physiology, Leptin:genetics, Pituitary Gland:physiology, Polymerase Chain Reaction, Pregnancy, Pregnancy, Animal:physiology, RNA, Messenger:genetics, Swine,.   

BACKGROUND: Leptin, the 16-kDa peptide hormone product of the ob gene, is a regulatory hormone secreted mainly by adipose tissue. Recent studies have shown leptin production by other tissues, including rat hypothalamus, rat and human pituitary, rat skeletal muscle, kidney and stomach, human and porcine placenta, human mammary epithelial cells as well as endometrial tissues. This hormone is a central modulator of food intake, metabolism and neuroendocrine functions.

OBJECTIVES: The aim of the study was to detect and locate porcine leptin gene expression in the different areas of the hypothalamus and pituitary on days 14-16 and 30-32 of pregnancy in pigs.

METHOD: Leptin gene expression was analysed by RT-PCR method. PCR products were subjected to sequencing analysis.

RESULTS: Leptin mRNA was expressed in the medial basal hypothalamus, preoptic area, stalk median eminence, anterior pituitary, posterior pituitary and adipose tissue on days 14-16 and 30-32 of pregnancy. Sequence analysis of the 258 bp product from the hypothalamus and pituitary confirmed 99% homology with the corresponding region of porcine leptin cDNA sequence.

CONCLUSION: Leptin mRNA expression in the porcine hypothalamus and pituitary gland implies its paracrine and/or autocrine role in the regulation of hypothalamic-pituitary axis activity....

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