Relevance of CYP2D6 variability in first-episode schizophrenia patients treated with risperidone.

Journal Article 2012; 33(2): 236-244 PubMed PMID: 22592207 Keywords: Adolescent, Adult, Aged, Alleles, Antipsychotic Agents:adverse effects, Cytochrome P-450 CYP2D6:genetics, Female, Genotype, Humans, Male, Middle Aged, Prospective Studies, Psychiatric Status Rating Scales:statistics & numerical data, Psychotic Disorders:d.

OBJECTIVE: The objective of this prospective, naturalistic study, conducted in first-episode psychosis patients from a Central-European po.....

Effects of combined treatment with cognitive enhancer memantine and antidepressant fluoxetine on CYP2D2 metabolic activity in rats.

Journal Article 2011; 32(5): 727-732 PubMed PMID: 22167136 Keywords: Animals, Antidepressive Agents:pharmacokinetics, Aryl Hydrocarbon Hydroxylases:metabolism, Brain:drug effects, Cognition:drug effects, Dextromethorphan:blood, Dopamine Agents:pharmacokinetics, Drug Interactions, Drug Therapy, Combination, Enzyme Activatio.

OBJECTIVES: The drug-drug interactions can result in alterations of the therapeutical responses. The present study was designed to investi.....

Journal Article 2009; 30(Suppl 1): 92-95 PubMed PMID: 20027151 Keywords: Animals, Biotransformation, Cytochrome P-450 Enzyme System:chemistry, Liver:drug effects, Male, Phenacetin:metabolism, Rats, Rats, Wistar, Time Factors, Tolbutamide:metabolism,.

OBJECTIVES: A "cocktail" of several substrates is frequently used to assess metabolic activity of multiple cytochrome P450 enzymes in one .....