Articles by author - V K Khavinson

DNA double-helix binds regulatory peptides similarly to transcription factors.

Khavinson V, Shataeva L, Chernova A.

Journal Article 2005; 26(3): 237-241 PubMed PMID: 15990728  Keywords:  Animals, DNA:chemistry, Entropy, Evolution, Molecular, Humans, Models, Chemical, Nucleic Acid Conformation, Peptides:chemistry, Promoter Regions, Genetic, Protein Binding, Protein Conformation, Transcription Factors:chemistry,.    Citation

PROBLEM: Gerontology observations show that ageing of organism is accompanied by the decrease of the chromatin activity and slowing down o.....

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Elucidation of the effect of brain cortex tetrapeptide Cortagen on gene expression in mouse heart by microarray.

Anisimov S, Khavinson V, Anisimov V.

Comparative Study 2004; 25(1-2): 87-93 PubMed PMID: 15159690  Keywords:  Animals, Cerebral Cortex:metabolism, DNA, Complementary:analysis, Dipeptides:physiology, Female, Gene Expression, Gene Expression Profiling, Melatonin:physiology, Mice, Mice, Inbred CBA, Myocardium:metabolism, Oligonucleotide Array Sequence Analysis, Olig.    Citation

OBJECTIVES: Aging is associated with significant alterations in gene expression in numerous organs and tissues. Anti-aging therapy with pe.....

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Peptide Epitalon activates chromatin at the old age.

Khavinson V, Lezhava T, Monaselidze J, Jokhadze T, Dvalishvili N, Bablishvili N, Trofimova S.

Journal Article 2003; 24(5): 329-333 PubMed PMID: 14647006  Keywords:  Aged, Aging:physiology, Cells, Cultured, Euchromatin:drug effects, Heterochromatin:drug effects, Hot Temperature, Humans, Lymphocytes:cytology, Oligopeptides:pharmacology, Protein Denaturation, Ribosomal Proteins:genetics, Transcriptional Activation:drug .    Citation

UNLABELLED: OBJECTIVES and design. We have studied the effect of synthetic peptide Epitalon on the activity of ribosomal genes, denaturati.....

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Peptides of pineal gland and thymus prolong human life.

Khavinson V, Morozov V.

Clinical Trial 2003; 24(3-4): 233-240 PubMed PMID: 14523363  Keywords:  Aged, Aged, 80 and over, Aging:pathology, Endocrine Glands:drug effects, Female, Health Status Indicators, Humans, Immunity:drug effects, Male, Metabolism:drug effects, Mortality, Peptides:pharmacology, Pineal Gland:chemistry, Respiratory Tract Diseases:e.    Citation

OBJECTIVES AND DESIGN: Researchers of the St. Petersburg Institute of Bioregulation and Gerontology of the North-Western Branch of the Rus.....

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Epitalon influences pineal secretion in stress-exposed rats in the daytime.

Sibarov D, Kovalenko R, Malinin V, Khavinson V.

Journal Article 2002; 23(5-6): 452-454 PubMed PMID: 12500171  Keywords:  Administration, Intranasal, Animals, Capillaries:drug effects, Food Deprivation, Male, Oligopeptides:administration & dosage, Photoperiod, Pineal Gland:blood supply, Proto-Oncogene Proteins c-fos:biosynthesis, Rats, Rats, Wistar, Stress, Physiological:phy.    Citation

OBJECTIVES: The content of C-Fos protein was tested in rat pinealocytes in the norm and stress and in case of intranasal administration of.....

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Effect of epitalon on interleukin-1beta signal transduction and the reaction of thymocyte blast transformation under stress.

Khavinson V, Korneva E, Malinin V, Rybakina E, Pivanovich I, Shanin S.

Journal Article 2002; 23(5-6): 411-416 PubMed PMID: 12500162  Keywords:  Animals, Cell Division:drug effects, Cell Membrane:chemistry, Cerebral Cortex:chemistry, Concanavalin A:pharmacology, Crosses, Genetic, Enzyme Activation:drug effects, Interleukin-1:metabolism, Lymphocyte Activation:drug effects, Male, Mice, Mice, Inbred .    Citation

OBJECTIVES: The aim of this research consisted in studying the effects of tetrapeptide Epitalon on both thymocyte proliferation and interl.....

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