Articles by author - René Kizek

Preparation and application of anti-peptide antibodies for detection of orphan cytochromes P450.

Hodek P, Hrdinova J, Macova I, Soucek P, Mrizova I, Burdova K, Kizek R, Hudecek J, Stiborova M.

Journal Article 2015; 36(Suppl 1): 38-45 PubMed PMID: 26757124  Keywords:  Animals, Antibodies:immunology, Antibody Formation, Blotting, Western, Cell Line, Tumor, Chickens, Cytochrome P-450 Enzyme System:immunology, Cytochrome P450 Family 2, Eggs, Electrophoresis, Gel, Two-Dimensional, Enzyme-Linked Immunosorbent Assay, Humans,.    Citation

OBJECTIVES: Cytochromes P450 (CYP) are monooxygenases, which metabolize mostly hydrophobic endogenous and exogenous compounds. CYPs withou.....

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Cytotoxicity of and DNA adduct formation by ellipticine and its micellar form in human leukemia cells in vitro.

Stiborova M, Manhartova Z, Hodek P, Adam V, Kizek R, Eckschlager T, Frei E.

Journal Article 2015; 36(Suppl 1): 22-28 PubMed PMID: 26757112  Keywords:  Animals, Antineoplastic Agents:pharmacology, Cell Survival:drug effects, DNA Adducts:drug effects, Ellipticines:pharmacology, HL-60 Cells, Humans, In Vitro Techniques, Liver:drug effects, Micelles, Rats,.    Citation

OBJECTIVES: The improvements of cancer treatment are the major challenge in oncology research. Nanocarriers are one of the promising appro.....

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Modulation of human cytochrome P450 1A1-mediated oxidation of benzo[a]pyrene by NADPH:cytochrome P450 oxidoreductase and cytochrome b5.

Indra R, Moserova M, Kroftova N, Sulc M, Martinkova M, Adam V, Eckschlager T, Kizek R, Arlt V, Stiborova M.

Journal Article 2014; 35(Suppl 2): 105-113 PubMed PMID: 25638374  Keywords:  Benzo(a)pyrene:metabolism, Cytochrome P-450 CYP1A1:metabolism, Cytochromes b5:metabolism, Humans, NADH, NADPH Oxidoreductases:metabolism,.    Citation

OBJECTIVES: Cytochrome P450 (CYP) 1A1 located in the membrane of endoplasmic reticulum is the most important enzyme in both activ.....

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Study of the influence of platinum, palladium and rhodium on duckweed (Lemna minor).

Bednarova I, Mikulaskova H, Havelkova B, Strakova L, Beklova M, Sochor J, Hynek D, Adam V, Kizek R.

Journal Article 2014; 35(Suppl 2): 35-42 PubMed PMID: 25638364  Keywords:  Environmental Monitoring, Palladium:toxicity, Plants:anatomy & histology, Platinum Compounds:toxicity, Rhodium:toxicity, Water Pollution, Chemical:adverse effects,.    Citation

OBJECTIVES: Road traffic pollutants and the residues of cytostatics that are widely used in anti-cancer therapy are a significant.....

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Yew poisoning of olive baboons (Papio anubis) in captivity: laboratory diagnosis.

Kominkova M, Stanisavljevic M, Zitka O, Mazanek S, Sedlackova J, Bandouchova H, Pikula J, Beklova M, Kizek R.

Case Reports 2013; 34(Suppl 2): 130-133 PubMed PMID: 24362105  Keywords:  Alkaloids:analysis, Animals, Animals, Zoo, Bile:chemistry, Blood Chemical Analysis:veterinary, Clinical Laboratory Techniques, Fatal Outcome, Female, Foodborne Diseases:diagnosis, Male, Monkey Diseases:diagnosis, Papio anubis:blood, Taxoids:analysis, Taxu.    Citation

OBJECTIVES: Toxic effects of the yew have been known since ancient times. Yew toxicity is due to the content of cyanogenic glycosides and .....

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Molecular biology of beta-estradiol-estrogen receptor complex binding to estrogen response element and the effect on cell proliferation.

Heger Z, Zitka O, Krizkova S, Beklova M, Kizek R, Adam V.

Journal Article 2013; 34(Suppl 2): 123-129 PubMed PMID: 24362104  Keywords:  Animals, Cell Proliferation:drug effects, Estradiol:metabolism, Gene Expression Regulation:drug effects, Humans, Male, Protein Binding:drug effects, Receptors, Estrogen:metabolism, Response Elements:drug effects,.    Citation

: Group of estrogen pollutants, where the highest estrogen activity is reported at estradiol, is characterized by the fact that even at ve.....

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