: The use of psychedelic drugs in minute doses as an adjuvant psychotherapeutic means, within the context of Athanassios Kafkalides' autopsychognosia, caused the emotional revival of prenatal and perinatal experiences. This mnemonic process gives rise to a wide range of gnosiological questions such as, inter alia, those regarding the use of psychedelic drugs to stimulate memories and the difference between emotional and intellectual realization in the quest for knowledge. The new findings in this field necessitated profound changes of concepts like truth, reality, subjectivity, objectivity, unconscious, consciousness, cause and effect, emotions, intellect, quality, quantity, etc. The study presented here will deal with these issues in the context of gnosiotheoretical stands supported by thinkers from Plato to Feyerabend.