OBJECTIVES: There is good evidence that opioids can potentiate analgesic activity of some older non-opioid analgesics (such as paracetamol.....
Janovsky M, Krsiak M. Codeine did not increase analgesic efficacy of coxibs in contrast to that of paracetamol or ibuprofen: isobolographic analysis in mice. Neuro Endocrinol Lett. 2011 Jan; 32(2): 164-169
Soukupová M, Palazzo E, De Chiaro M, Gatta L, Migliozzi A, Guida F, Luongo L, Giordano C, Siniscalco D, De Novellis V, Marabese I, Krsiak M, Maione S.
Journal Article 2010; 31(4): 507-511 PubMed PMID: 20802454 Keywords: Acetaminophen:pharmacology, Amidohydrolases:antagonists & inhibitors, Analgesics, Non-Narcotic:pharmacology, Animals, Benzamides:pharmacology, Carbamates:pharmacology, Dose-Response Relationship, Drug, Drug Interactions, Linear Models, Male, Mice, Pain Me. CitationOBJECTIVES: Paracetamol is converted to an active metabolite AM404 via fatty acid amide hydrolase (FAAH). The aim of the present study was.....
Soukupová M, Palazzo E, De Chiaro M, Gatta L, Migliozzi A, Guida F, Luongo L, Giordano C, Siniscalco D, De Novellis V, Marabese I, Krsiak M, Maione S. Effects of URB597, an inhibitor of fatty acid amide hydrolase (FAAH), on analgesic activity of paracetamol. Neuro Endocrinol Lett. 2010 Jan; 31(4): 507-511
Sustková-Fiserová M, Vávrová J, Krsiak M.
Comparative Study 2009; 30(1): 79-84 PubMed PMID: 19300401 Keywords: Aggression:physiology, Animals, Aspartic Acid:analysis, Behavior, Animal:physiology, Brain:metabolism, Excitatory Amino Acids:analysis, Glutamic Acid:analysis, Male, Mice, Mice, Inbred ICR, Microchemistry:methods, Microdialysis:methods, Models, Biological. CitationOBJECTIVES: Some individually-housed male mice behave aggressively during encounters with strange males, while others are timid or sociabl.....
Sustková-Fiserová M, Vávrová J, Krsiak M. Brain levels of GABA, glutamate and aspartate in sociable, aggressive and timid mice: an in vivo microdialysis study. Neuro Endocrinol Lett. 2009 Mar; 30(1): 79-84
Sliva J, Dolezal T, Sykora D, Vosmanska M, Krsiak M.
Journal Article 2009; 30(3): 352-356 PubMed PMID: 19855358 Keywords: Acetic Acid:toxicity, Analgesia, Analysis of Variance, Animals, Anti-Inflammatory Agents, Non-Steroidal:pharmacology, Celecoxib, Chromatography, High Pressure Liquid, Dose-Response Relationship, Drug, Drug Synergism, Expectorants:administration & dosage, . CitationOBJECTIVES: Previously, we found that guaifenesin enhances analgesia induced by paracetamol. The aim of the present study was to determine.....
Sliva J, Dolezal T, Sykora D, Vosmanska M, Krsiak M. Guaifenesin enhances the analgesic potency of ibuprofen, nimesulide and celecoxib in mice. Neuro Endocrinol Lett. 2009 Jan; 30(3): 352-356
Soukupova M, Dolezal T, Krsiak M.
Journal Article 2009; 30(2): 215-220 PubMed PMID: 19675513 Keywords: Acetic Acid, Adrenergic alpha-Agonists:pharmacology, Analgesics, Non-Narcotic:pharmacology, Analysis of Variance, Animals, Dose-Response Relationship, Drug, Drug Synergism, Ibuprofen:pharmacology, Male, Mice, Motor Activity:drug effects, Oxazoles:pharmaco. CitationOBJECTIVES: The aim of the study was to ascertain whether rilmenidine, a second generation imidazoline-alpha-2-adrenoreceptor agonist, is .....
Soukupova M, Dolezal T, Krsiak M. Synergistic interaction between rilmenidine and ibuprofen in the writhing test in mice. Neuro Endocrinol Lett. 2009 Jan; 30(2): 215-220
Sliva J, Dolezal T, Prochazkova M, Votava M, Krsiak M.
Comparative Study 2008; 29(6): 953-957 PubMed PMID: 19112399 Keywords: Analgesics:administration & dosage, Analysis of Variance, Animals, Anticonvulsants:administration & dosage, Disease Models, Animal, Dose-Response Relationship, Drug, Male, Morphine:administration & dosage, Pain, Postoperative:prevention & control, Piracet. CitationOBJECTIVES: Preemptive versus therapeutic effects of levetiracetam were investigated in a model of postoperative incisional pain in rats.<.....
Sliva J, Dolezal T, Prochazkova M, Votava M, Krsiak M. Preemptive levetiracetam decreases postoperative pain in rats. Neuro Endocrinol Lett. 2008 Dec; 29(6): 953-957