Articles by author - Antonín Lojek

Different effect of two synthetic coumarin-stilbene hybrid compounds on phagocyte activity.

Drabikova K, Perecko T, Nosal R, Rackova L, Ambrozova G, Lojek A, Smidrkal J, Harmatha J, Jancinova V.

Journal Article 2010; 31(Suppl 2): 73-78 PubMed PMID: 21187835  Keywords:  Adult, Animals, Cell Line, Coumarins:pharmacology, Humans, Lipopolysaccharides:pharmacology, Macrophages:cytology, Male, Mice, Middle Aged, Models, Animal, Neutrophils:cytology, Nitric Oxide:metabolism, Phagocytosis:drug effects, Reactive Oxygen Species:m.    Citation

OBJECTIVE: Activated phagocytes, generating a variety of powerful inflammatory mediators, such as oxygen and nitrogen species, may partici.....

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Formation of reactive oxygen and nitrogen species in the presence of pinosylvin - an analogue of resveratrol.

Jancinova V, Nosal R, Lojek A, Ciz M, Ambrozova G, Mihalova D, Bauerova K, Harmatha J, Perecko T.

Journal Article 2010; 31(Suppl 2): 79-83 PubMed PMID: 21187828  Keywords:  Animals, Antioxidants:pharmacology, Antirheumatic Agents:therapeutic use, Arthritis, Experimental:drug therapy, Cell Line, Disease Models, Animal, Drug Therapy, Combination, Macrophages:cytology, Male, Methotrexate:therapeutic use, Neutrophils:drug effect.    Citation

OBJECTIVE: Formation of reactive oxygen species in neutrophils of rats with adjuvant arthritis and generation of nitric oxide in RAW 264.7.....

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Molecular targets of the natural antioxidant pterostilbene: effect on protein kinase C, caspase-3 and apoptosis in human neutrophils in vitro.

Perecko T, Drabikova K, Rackova L, Ciz M, Podborska M, Lojek A, Harmatha J, Smidrkal J, Nosal R, Jancinova V.

Journal Article 2010; 31(Suppl 2): 84-90 PubMed PMID: 21187824  Keywords:  Antioxidants:pharmacology, Apoptosis:drug effects, Caspase 3:metabolism, Cell Survival:drug effects, Computer Simulation, Dose-Response Relationship, Drug, Humans, In Vitro Techniques, Male, Neutrophils:cytology, Phosphorylation:drug effects, Protein Kina.    Citation

OBJECTIVE: Pterostilbene, a naturally occurring phenolic derivative, exhibits various pharmacological effects, e.g. anti-cancerous, antiox.....

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H1-antihistamines and oxidative burst of professional phagocytes.

Nosal R, Drabikova K, Jancinova V, Moravcova J, Lojek A, Ciz M, Macickova T, Pecivova J.

Comparative Study 2009; 30(Suppl 1): 133-136 PubMed PMID: 20027159  Keywords:  Benzothiepins:pharmacology, Brompheniramine:pharmacology, Chlorpheniramine:pharmacology, Dose-Response Relationship, Drug, Extracellular Space:drug effects, Histamine H1 Antagonists:administration & dosage, Humans, Intracellular Space:drug effects, Lorata.    Citation

OBJECTIVES: We analysed and compared the effect of five H1-antihistamines on stimulated oxidative burst at extra- and intracellular level .....

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Interactions of oxidatively modified calf skin collagen with platelets and phagocytes.

Ciz M, Cizova H, Pejchalova K, Jancinova V, Goshev I, Mihaylova B, Nosal R, Lojek A.

Journal Article 2009; 30(Suppl 1): 128-132 PubMed PMID: 20027158  Keywords:  Absorption, Animals, Cattle, Centrifugation, Collagen Type I:chemistry, Electrophoresis, Polyacrylamide Gel, Humans, Hydrogen Peroxide:chemistry, Hydroxyl Radical:chemistry, Luminescence, Oxidation-Reduction, Phagocytes:metabolism, Platelet Aggregation, P.    Citation

OBJECTIVES: The effects of non-modified and oxidatively modified calf skin collagen type I on platelet aggregation and the oxidative burst.....

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Increased markers of oxidative stress in plasma of patients with chronic pancreatitis.

Podborska M, Sevcikova A, Trna J, Dite P, Lojek A, Kubala L.

Journal Article 2009; 30(Suppl 1): 116-120 PubMed PMID: 20027156  Keywords:  Adult, Aldehydes:blood, Antioxidants:metabolism, C-Reactive Protein:metabolism, Cholesterol, HDL:blood, Chromatography, High Pressure Liquid, Female, Humans, Luminescent Measurements, Male, Malondialdehyde:blood, Middle Aged, Nitrites:blood, Oxidative Str.    Citation

OBJECTIVES: Chronic pancreatitis (CP) is a heterogeneous disease defined as chronic inflammatory changes of the pancreatic tissue caused b.....

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