: Benign Myalgic Encephalomyelitis (ME) / Chronic Fatigue Syndrome (CFS) is a debilitating disease which, despite numerous biological abno.....
Twisk F, Maes M. A review on cognitive behavorial therapy (CBT) and graded exercise therapy (GET) in myalgic encephalomyelitis (ME) / chronic fatigue syndrome (CFS): CBT/GET is not only ineffective and not evidence-based, but also potentially harmful for many patients wit Neuro Endocrinol Lett. 2009 Jan; 30(3): 284-299
BACKGROUND: There is now evidence that an increased translocation of LPS from gram negative bacteria with subsequent gut-derived inflammat.....
Maes M, Leunis J. Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria. Neuro Endocrinol Lett. 2008 Dec; 29(6): 902-910
Maes M, Mihaylova I, Kubera M, Leunis J.
Journal Article 2008; 29(3): 313-319 PubMed PMID: 18580855 Keywords: Adult, Analysis of Variance, Blood-Air Barrier:physiology, Depressive Disorder, Major:complications, Fatigue Syndrome, Chronic:complications, Female, Humans, Immunoglobulin A:immunology, Immunoglobulin M:immunology, Intestinal Mucosa:physiology, Male, Mid. CitationBACKGROUND: It has been shown that chronic fatigue syndrome (CFS) and major depression (MDD) are accompanied by signs of oxidative stress .....
Maes M, Mihaylova I, Kubera M, Leunis J. An IgM-mediated immune response directed against nitro-bovine serum albumin (nitro-BSA) in chronic fatigue syndrome (CFS) and major depression: evidence that nitrosative stress is another factor underpinning the comorbidity between major depression and CF Neuro Endocrinol Lett. 2008 Jun; 29(3): 313-319
Croonenberghs J, Spaas K, Wauters A, Verkerk R, Scharpe S, Deboutte D, Maes M.
Journal Article 2008; 29(3): 385-390 PubMed PMID: 18580847 Keywords: 5-Hydroxytryptophan, Adolescent, Analysis of Variance, Autistic Disorder:blood, Dehydroepiandrosterone Sulfate:blood, Humans, Hydrocortisone:blood, Male, Psychiatric Status Rating Scales, Serotonin:blood, Single-Blind Method,. CitationBACKGROUND: Autism is accompanied by peripheral and central disorders in the metabolism of serotonin (5-HT). The present study examines pl.....
Croonenberghs J, Spaas K, Wauters A, Verkerk R, Scharpe S, Deboutte D, Maes M. Faulty serotonin--DHEA interactions in autism: results of the 5-hydroxytryptophan challenge test. Neuro Endocrinol Lett. 2008 Jun; 29(3): 385-390
: This paper hypothesizes that inflammatory, oxidative and nitrosative (IO&NS) pathways, and an increased translocation of LPS from gram-n.....
Maes M. The cytokine hypothesis of depression: inflammation, oxidative & nitrosative stress (IO&NS) and leaky gut as new targets for adjunctive treatments in depression. Neuro Endocrinol Lett. 2008 Jun; 29(3): 287-291
: There is now evidence that major depression (MDD) is accompanied by an activation of the inflammatory response system (IRS) and that pro.....
Maes M, Kubera M, Leunis J. The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression. Neuro Endocrinol Lett. 2008 Feb; 29(1): 117-124