Variations in critical morphine biosynthesis genes and their potential to influence human health.

Journal Article 2010; 31(1): 11-18 PubMed PMID: 20150871 Keywords: Cannabinoid Receptor Modulators:biosynthesis, Catechol O-Methyltransferase:genetics, Cytochrome P-450 CYP2D6:genetics, Enzymes:genetics, Genetic Predisposition to Disease, Health, Humans, Mental Disorders:genetics, Metabolic Networks and Pathways:genetics.

: Endogenous morphine has been detected in human tissues from the vascular, immune and nervous systems. The genes/enzymes (CYP2D6, COMT an.....

The American lobster, Homarus americanus, contains morphine that is coupled to nitric oxide release in its nervous and immune tissues: Evidence for neurotransmitter and hormonal signaling.

Comparative Study 2005; 26(2): 89-97 PubMed PMID: 15855878 Keywords: Analysis of Variance, Animals, Base Sequence, Hemolymph:metabolism, Humans, Molecular Sequence Data, Morphine:metabolism, Nephropidae:metabolism, Nerve Tissue Proteins:metabolism, Nervous System:metabolism, Nitric Oxide:secretion, Nitric Oxide Synthase:me.

OBJECTIVES: The study was designed to determine if morphine was present in lobster tissues. It was also important to determine, as in othe.....

Comparative Study 2004; 25(5): 323-330 PubMed PMID: 15580165 Keywords: Alkaloids:administration & dosage, Animals, Benzylisoquinolines:administration & dosage, Bivalvia:metabolism, Cell Line, Dose-Response Relationship, Drug, Ganglia, Invertebrate:metabolism, Humans, Monocytes:drug effects, Morphine:metabolism, Nitric Oxide:.

OBJECTIVES: Given the presence of morphine, its metabolites and precursors in mammalian and invertebrate tissues, it became important to d.....

Journal Article 2004; 25(1-2): 57-61 PubMed PMID: 15159684 Keywords: Animals, Bivalvia, Enzyme Inhibitors:pharmacology, Feedback, Physiological:physiology, Ganglia, Invertebrate:cytology, Interleukin-1:physiology, Leukocytes:drug effects, Lymphocyte Activation:physiology, NG-Nitroarginine Methyl Ester:pharmacology, Neuroim.

: Pedal ganglia excised and maintained in culture for up to 2 h, release NO at low levels. The range can vary between 0 to 1.1 nM. Non-sti.....

Journal Article 2003; 24(3-4): 137-140 PubMed PMID: 14523346 Keywords: Animals, Bivalvia:metabolism, Chromatography, High Pressure Liquid, Estradiol:metabolism, Gonads:metabolism, Isomerism, Radioimmunoassay, Reproduction:physiology, Spectrometry, Mass, Electrospray Ionization, Spectrophotometry, Ultraviolet,.

OBJECTIVES: In earlier studies, we demonstrate that 17-beta -estradiol and an estrogen cell surface receptor can be found on various human.....

Journal Article 2003; 24(3-4): 130-136 PubMed PMID: 14523345 Keywords: Animals, Base Sequence, Bivalvia:metabolism, Cell Movement:drug effects, Cloning, Molecular, Down-Regulation:drug effects, Enzyme Inhibitors:pharmacology, Estradiol:pharmacology, Estrogen Receptor beta, Ganglia, Invertebrate:cytology, In Vitro Techniques,.

OBJECTIVES: In earlier studies we have demonstrated that 17-beta-estradiol and an estrogen cell surface receptor can be found on various h.....