Culka M, Milichovsky J, Jerabek P, Stiborova M, Martinek V.
Journal Article 2015; 36(Suppl 1): 29-37 PubMed PMID: 26757119 Keywords: Aryl Hydrocarbon Hydroxylases:metabolism, Cytochrome P-450 CYP1A1:metabolism, Cytochrome P-450 CYP1A2:metabolism, Cytochrome P-450 CYP2A6:metabolism, Cytochrome P-450 CYP2B6:metabolism, Cytochrome P-450 CYP2C8:metabolism, Cytochrome P-450 CYP2C9:metabolis. CitationOBJECTIVES: Cytochromes P450 (CYPs) are heme enzymes oxygenating a broad range of substrates. Their activity is dependent on the presence .....
Culka M, Milichovsky J, Jerabek P, Stiborova M, Martinek V. Ferrous and ferric state of cytochromes P450 in intact Escherichia coli cells: a possible role of cytochrome P450-flavodoxin interactions. Neuro Endocrinol Lett. 2015 Jan; 36(Suppl 1): 29-37
Tóthová V, Bártlová S, Dolák F, Kaas J, Kimmer D, Maňhalová J, Martinek L, Olišarová V.
Journal Article 2014; 35(Suppl 1): 11-18 PubMed PMID: 25433349 Keywords: Activities of Daily Living, Adult, Arthritis, Rheumatoid:physiopathology, Chronic Disease, Crohn Disease:physiopathology, Czech Republic, Female, Health Surveys, Humans, Male, Middle Aged, Peripheral Arterial Disease:physiopathology, Pulmonary Disease, Ch. CitationOBJECTIVES: A quality of life assessment is of great importance for patients with chronic diseases, because problems caused by specific di.....
Tóthová V, Bártlová S, Dolák F, Kaas J, Kimmer D, Maňhalová J, Martinek L, Olišarová V. Quality of life in patients with chronic diseases. Neuro Endocrinol Lett. 2014 Jan; 35(Suppl 1): 11-18
Sulc M, Jecmen T, Snajdrova R, Novak P, Martinek V, Hodek P, Stiborova M, Hudecek J.
Journal Article 2012; 33(Suppl 3): 41-47 PubMed PMID: 23353842 Keywords: Animals, Aryl Hydrocarbon Hydroxylases:chemistry, Carbodiimides:chemistry, Chromatography, Liquid:methods, Cross-Linking Reagents:chemistry, Cytochrome P450 Family 2, Cytochromes b5:chemistry, Dimerization, Electrons, Mass Spectrometry:methods, Microsomes. CitationOBJECTIVES: The cytochrome P450 (P450) and cytochrome b5 are membrane hemoproteins composing together with flavoprotein NADPH:P450 reducta.....
Sulc M, Jecmen T, Snajdrova R, Novak P, Martinek V, Hodek P, Stiborova M, Hudecek J. Mapping of interaction between cytochrome P450 2B4 and cytochrome b5: the first evidence of two mutual orientations. Neuro Endocrinol Lett. 2012 Jan; 33(Suppl 3): 41-47
Jerabek P, Martinek V, Stiborova M.
Journal Article 2012; 33(Suppl 3): 25-32 PubMed PMID: 23353840 Keywords: Amino Acid Sequence, Aristolochia:chemistry, Aristolochic Acids:adverse effects, Aryl Hydrocarbon Hydroxylases:chemistry, Catalytic Domain:drug effects, Computer Simulation, Cytochrome P-450 CYP1A1:chemistry, Cytochrome P-450 CYP1A2:chemistry, Cytochrome . CitationOBJECTIVES: The herbal drug aristolochic acid (AA) derived from Aristolochia species has been shown to be the cause of aristolochic acid n.....
Jerabek P, Martinek V, Stiborova M. Theoretical investigation of differences in nitroreduction of aristolochic acid I by cytochromes P450 1A1, 1A2 and 1B1. Neuro Endocrinol Lett. 2012 Jan; 33(Suppl 3): 25-32
Martinek V, Kubickova B, Arlt V, Frei E, Schmeiser H, Hudecek J, Stiborova M.
Comparative Study 2011; 32(Suppl 1): 57-70 PubMed PMID: 22167209 Keywords: Acetyltransferases:chemistry, Animals, Aristolochic Acids:chemistry, Biotransformation:physiology, Catalytic Domain, Cells, Cultured, DNA Adducts:metabolism, Enzyme Activation, Humans, Lactams:metabolism, Models, Molecular, Molecular Conformation, NAD(P)H. CitationOBJECTIVES: Ingestion of aristolochic acid (AA) is associated with development of urothelial tumors linked with aristolochic acid nephropa.....
Martinek V, Kubickova B, Arlt V, Frei E, Schmeiser H, Hudecek J, Stiborova M. Comparison of activation of aristolochic acid I and II with NADPH:quinone oxidoreductase, sulphotransferases and N-acetyltranferases. Neuro Endocrinol Lett. 2011 Jan; 32(Suppl 1): 57-70
Mrazova B, Martinek V, Martinkova M, Sulc M, Frei E, Stiborova M.
Journal Article 2009; 30(Suppl 1): 72-79 PubMed PMID: 20027148 Keywords: Absorption, Amino Acid Sequence, Animals, Apoproteins:chemistry, Butanones, Chromatography, Cytochromes b5:chemistry, Electrons, Electrophoresis, Polyacrylamide Gel, Heme:chemistry, Horses, Hydrogen-Ion Concentration, Mass Spectrometry, Molecular Sequence. CitationOBJECTIVES: Cytochrome b5 (cyt b5), a component of endoplasmic reticulum membrane, plays a role in modulation of activity of several cytoc.....
Mrazova B, Martinek V, Martinkova M, Sulc M, Frei E, Stiborova M. Preparation of apo-cytochrome b5 utilizing heme transfer to apo-myoglobin. Neuro Endocrinol Lett. 2009 Jan; 30(Suppl 1): 72-79