Cytotoxicity of and DNA adduct formation by ellipticine in human U87MG glioblastoma cancer cells.

Journal Article 2009; 30(Suppl 1): 60-66 PubMed PMID: 20027146 Keywords: Antineoplastic Agents:administration & dosage, Autoradiography, Blotting, Western, Cell Line, Tumor, Cell Proliferation:drug effects, Cell Survival:drug effects, Chromatography, High Pressure Liquid, Cytochrome P-450 Enzyme System:metabolism, DNA Adducts:.

OBJECTIVES: Ellipticine is a potent antineoplastic agent exhibiting multiple mechanisms of action with promising brain tumor specificity. .....

Rat cytochromes P450 oxidize 2-nitrophenol, a human metabolite of carcinogenic 2-nitroanisole.

Journal Article 2009; 30(Suppl 1): 46-51 PubMed PMID: 20027144 Keywords: Animals, Anisoles:metabolism, Chromatography, High Pressure Liquid:methods, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System:metabolism, Humans, Inhibitory Concentration 50, Kinetics, Microsomes, Liver:enzymology, Nitrophenols:metabolism.

OBJECTIVES: 2-Nitrophenol (2-NP) is the major detoxification metabolite of an important industrial pollutant and a potent carcinogen, 2-ni.....

Journal Article 2009; 30(3): 400-402 PubMed PMID: 19855367 Keywords: Adult, Analysis of Variance, Biomarkers, Chlorine:analysis, Creatinine:analysis, Female, Glucose:analysis, Humans, Lactic Acid:analysis, Magnesium:analysis, Male, Panic Disorder:metabolism, Potassium:analysis, Sodium:analysis, Sweat:chemistry, Sweating,.

OBJECTIVE: Panic disorder (PD) is a paroxysmal neuropsychiatric disorder with unclear etiology and obscure pathophysiology. Despite the fr.....