Metabolic characteristics of women diagnosed with polycystic ovary syndrome (PCOS) according to the Rotterdam criteria - our own experience.

OBJECTIVES: Analysis of metabolic features of women diagnosed with the PCOS among female patients of Department of Endocrinology and Metabolic Diseases, the Polish Mother's Memorial Hospital - Research Institute (DEMD, PMMH-RI). The secondary aim was assessment if diagnosis of PCOS (according to the Rotterdam criteria) may imply any standard treatment. MATERIAL AND METHODS: The study was retrospective analysis of patients hospitalized in DEMD. 62 females diagnosed with PCOS were compared with women without the syndrome, adjusted according to the age and BMI. The parameters compared comprised insulin resistance assessed by five different methods (HOMA, HOMA2, QUICKI, IRI and Matsuda Index) and lipid concentration (total cholesterol, HDL-cholesterol and triglycerides). RESULTS: None of analyzed parameters (insulin resistance indices, lipid fractions concentrations) differed significantly between women diagnosed with PCOS and those without PCOS, adjusted according to age and BMI. Insulin resistance indices correlated with the BMI values. CONCLUSIONS: The metabolic characteristics of women diagnosed with the PCOS according to the Rotterdam criteria can be variant. PCOS is not necessarily connected with insulin resistance and obesity. Diagnosis of PCOS does not determine metabolic state of the individual so it should be postulated that every diagnosis of PCOS should by specified by information about the phenotype. Only precise information about the phenotype allows assessing the metabolic and cardiovascular risk and introducing optimal treatment.