Tapentadol in an Experimental Animal Model of Acute Orofacial Pain. Fricova J, Rokyta R, Nedvidek J. Journal Article 2019; 39(7): 496-500 PubMed PMID: 30860681 Keywords: Acute Pain:drug therapy, Analgesics, Opioid:therapeutic use, Animals, Central Amygdaloid Nucleus:physiology, Dose-Response Relationship, Drug, Facial Pain:drug therapy, Naloxone:pharmacology, Pain Measurement:methods, Pilot Projects, Rats, Tapentadol:anta. Citation OBJECTIVE: Tapentadol exhibits a synergistic dual effect effect (MOR / NRI) -agonist effect on noradrena-line reuptake inhibition (NRI). T..... Read abstract Full text PDF