Articles by author - Rado Nosál'

Effect of carvedilol on reactive oxygen species and enzymes linking innate and adaptive immunity.

Pecivová J, Macicková T, Lojek A, Gallová L, Cíz M, Nosál' R, Holománová D.

Journal Article 2006; 27(Suppl 2): 160-163 PubMed PMID: 17159805  Keywords:  Animals, Carbazoles:pharmacology, Cells, Cultured, Immunity, Cellular:drug effects, Immunity, Innate:drug effects, Macrophages:drug effects, Mice, N-Formylmethionine Leucyl-Phenylalanine:pharmacology, Nitric Oxide Synthase Type II:metabolism, Peroxidase:m.    Citation

OBJECTIVES: Neutrophils and macrophages are critical components of our innate host defenses. They are a potential source of nitric oxide (.....

Read abstract

Ischaemia/reperfusion-induced organ injury in low dose streptozotocin diabetes.

Nosál'ová V, Drábiková K, Zúrová-Nedelcevová J, Jancinová V, Okruhlicová L, Nosál' R, Sotníková R.

Journal Article 2006; 27(Suppl 2): 152-155 PubMed PMID: 17159803  Keywords:  Animals, Diabetes Mellitus, Experimental:complications, Diabetic Angiopathies:pathology, Dose-Response Relationship, Drug, Intestinal Diseases:complications, Intestine, Small:blood supply, Male, Mesenteric Artery, Superior:metabolism, Phenylephrine:pharma.    Citation

OBJECTIVES: The influence of low dose streptozotocin diabetes on intestinal and vascular injury induced by mesenteric ischaemia/reperfusio.....

Read abstract

On the pharmacology and toxicology of neutrophils.

Nosál' R, Drábiková K, Jancinová V, Macicková T, Pecivová J, Holománová D.

Comparative Study 2006; 27(Suppl 2): 148-151 PubMed PMID: 17159802  Keywords:  Benzothiepins:pharmacology, Histamine:pharmacology, Histamine H1 Antagonists:pharmacology, Humans, Loratadine:pharmacology, Neutrophils:drug effects, Peroxidase:metabolism, Superoxide Dismutase:metabolism, Tetradecanoylphorbol Acetate:pharmacology,.    Citation

OBJECTIVES: To study the effect of H1-antihistamines dithiaden (Dit) and loratadine (Lor) and compare it with that of histamine (His) on p.....

Read abstract

Extra- and intracellular formation of reactive oxygen species by human neutrophils in the presence of pheniramine, chlorpheniramine and brompheniramine.

Jancinová V, Drábiková K, Nosál' R, Holománová D.

Comparative Study 2006; 27(Suppl 2): 141-143 PubMed PMID: 17159800  Keywords:  Brompheniramine:pharmacology, Chlorpheniramine:pharmacology, Extracellular Fluid:metabolism, Histamine H1 Antagonists:pharmacology, Humans, Intracellular Fluid:metabolism, Luminescence, Neutrophils:drug effects, Pheniramine:pharmacology, Reactive Oxygen S.    Citation

BACKGROUND: Allergic inflammation was found to be accompanied by activation of neutrophils. Since this resulted in increased formation of .....

Read abstract

On the antioxidant activity of carvedilol in human polymorphonuclear leukocytes in vitro and ex vivo.

Drábiková K, Jancinová V, Nosál' R, Solík P, Murín J, Holománová D.

Clinical Trial 2006; 27(Suppl 2): 138-140 PubMed PMID: 17159799  Keywords:  Adrenergic beta-Antagonists:pharmacology, Aged, Antihypertensive Agents:therapeutic use, Antioxidants:pharmacology, Carbazoles:pharmacology, Diabetes Mellitus, Type 2:blood, Diabetic Angiopathies:blood, Female, Heart Failure:blood, Humans, In Vitro Techni.    Citation

OBJECTIVES: In the present study we investigated whether the beta-adrenoceptor antagonist carvedilol (CARV) [Dilatrend] prevented reactive.....

Read abstract