Articles by author - Tomas Novak

Relationship of ketamine's antidepressant and psychotomimetic effects in unipolar depression.

Sos P, Klirova M, Novak T, Kohutova B, Horacek J, Palenicek T.

Journal Article 2013; 34(4): 287-293 PubMed PMID: 23803871  Keywords:  Adult, Antidepressive Agents:therapeutic use, Cross-Over Studies, Depressive Disorder, Major:drug therapy, Double-Blind Method, Female, Hallucinogens:therapeutic use, Humans, Infusions, Intravenous, Ketamine:therapeutic use, Male, Middle Aged, Receptors, .    Citation

OBJECTIVES: Ketamine and other NMDA (N-methyl-D-aspartate) antagonists produce fast-acting antidepressant-like effects, although the under.....

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Mapping of interaction between cytochrome P450 2B4 and cytochrome b5: the first evidence of two mutual orientations.

Sulc M, Jecmen T, Snajdrova R, Novak P, Martinek V, Hodek P, Stiborova M, Hudecek J.

Journal Article 2012; 33(Suppl 3): 41-47 PubMed PMID: 23353842  Keywords:  Animals, Aryl Hydrocarbon Hydroxylases:chemistry, Carbodiimides:chemistry, Chromatography, Liquid:methods, Cross-Linking Reagents:chemistry, Cytochrome P450 Family 2, Cytochromes b5:chemistry, Dimerization, Electrons, Mass Spectrometry:methods, Microsomes.    Citation

OBJECTIVES: The cytochrome P450 (P450) and cytochrome b5 are membrane hemoproteins composing together with flavoprotein NADPH:P450 reducta.....

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Is combined treatment more effective than switching to monotherapy in patients with resistant depression? A retrospective study.

Bares M, Novak T, Kopecek M, Stopkova P, Sos P.

Journal Article 2009; 30(6): 723-728 PubMed PMID: 20038931  Keywords:  Adult, Antidepressive Agents:administration & dosage, Depressive Disorder, Major:diagnosis, Drug Resistance, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Retrospective Studies, Secondary Prevention, Sever.    Citation

OBJECTIVE: The aim of this retrospective study was to compare the efficacy of combination therapy (combinations of antidepressants and var.....

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Psychological dissociation in obsessive-compulsive disorder is associated with anxiety level but not with severity of obsessive-compulsive symptoms.

Raszka M, Prasko J, Koprivová J, Novák T, Adamcová K.

Journal Article 2009; 30(5): 624-628 PubMed PMID: 20035254  Keywords:  Adolescent, Adult, Anxiety:physiopathology, Female, Humans, Male, Middle Aged, Obsessive-Compulsive Disorder:physiopathology, Severity of Illness Index, Young Adult,.    Citation

OBJECTIVE: According to recent findings, clinical symptoms in patients with obsessive-compulsive disorder (OCD) seem be related with disso.....

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7-Hydroxylated derivatives of dehydroepiandrosterone in the human ventricular cerebrospinal fluid.

Starka L, Hill M, Kancheva R, Novak Z, Chrastina J, Pohanka M, Morfin R.

Journal Article 2009; 30(3): 368-372 PubMed PMID: 19855361  Keywords:  Adult, Androstenols:blood, Dehydroepiandrosterone:analogs & derivatives, Female, Humans, Hydrocephalus:blood, Male, Mass Spectrometry,.    Citation

OBJECTIVE: Dehydroepiandrosterone is a long established neuroactive steroid. Some authors documented that 7-oxygenated derivatives of this.....

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QEEG changes during switch from depression to hypomania/mania: a case report.

Kopecek M, Tislerova B, Sos P, Bares M, Novak T, Krajca V, Brunovsky M.

Case Reports 2008; 29(3): 295-302 PubMed PMID: 18580843  Keywords:  Antidepressive Agents, Tricyclic:therapeutic use, Bipolar Disorder:drug therapy, Brain:pathology, Clomipramine:therapeutic use, Depression:drug therapy, Electroencephalography, Humans, Magnetoencephalography, Male, Middle Aged, Parietal Lobe:physiology, R.    Citation

BACKGROUND: QEEG cordance and low-resolution electromagnetic tomography (LORETA) are relatively new applications of QEEG. Four small-scale.....

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