Effects of central and peripheral administration of leptin on pain threshold in rats and mice. Kutlu S, Canpolat S, Sandal S, Ozcan M, Sarsilmaz M, Kelestimur H. Comparative Study 2003; 24(3-4): 193-196 PubMed PMID: 14523356 Keywords: Animals, Hot Temperature, Injections, Intraperitoneal, Injections, Intraventricular, Leptin:administration & dosage, Male, Mice, Pain Measurement:drug effects, Pain Threshold:drug effects, Rats, Rats, Wistar, Reaction Time:drug effects,. Citation OBJECTIVE: This study was planned to investigate the effects of exogenous leptin on the pain threshold. METHODS: A..... Read abstract