Articles by author - Miroslav Pohanka

Tacrine alters antibodies level in Francisella tularensis-infected mice.

Pohanka M, Pavlis O, Pikula J.

Journal Article 2013; 34(Suppl 2): 134-137 PubMed PMID: 24362106  Keywords:  Animals, Antibodies, Bacterial:blood, Antibody Formation:drug effects, Cholinesterase Inhibitors:pharmacology, Dose-Response Relationship, Drug, Female, Francisella tularensis:drug effects, Immunity, Innate:drug effects, Mice, Mice, Inbred BALB C, Tacrine.    Citation

OBJECTIVES: Tacrine is an inhibitor of acetylcholinestrase (AChE) formerly used to treat cognitive impairment of Alzheimer disease. In pre.....

Read abstract  Full text PDF

Melatonin influences antioxidant homeostasis and basal metabolism in the BALB/c mouse model.

Pohanka M, Bandouchova H, Pikula J.

Journal Article 2012; 33(Suppl 3): 183-189 PubMed PMID: 23353865  Keywords:  Animals, Antioxidants:metabolism, Basal Metabolism:drug effects, Biomarkers:metabolism, Caspases:metabolism, Female, Homeostasis:drug effects, Melatonin:metabolism, Mice, Mice, Inbred BALB C, Models, Animal, Oxidative Stress:drug effects, Thiobarbituric A.    Citation

OBJECTIVES: Melatonin is a hormone with strong antioxidant activity. It is biosynthesized in the pineal gland and serves in the biological.....

Read abstract  Full text PDF

Avian high-dose toxicity of cyanobacterial biomass.

Kral J, Pikula J, Bandouchova H, Damkova V, Hilscherova K, Misik J, Novotny L, Ondracek K, Osickova J, Mlcakova V, Pohanka M, Skochova H, Vitula F, Treml F.

Journal Article 2012; 33(Suppl 3): 161-165 PubMed PMID: 23353861  Keywords:  Animals, Bacterial Toxins:toxicity, Biomass, Body Weight, Carcinogens:toxicity, Chemical and Drug Induced Liver Injury:epidemiology, Coturnix, Cyanobacteria:chemistry, Dose-Response Relationship, Drug, Hepatocytes:drug effects, Lethal Dose 50, Male, Marin.    Citation

OBJECTIVES: Previous studies using oral administration of environmentally relevant doses of cyanobacterial biomass containing microcystins.....

Read abstract  Full text PDF

Risk of combined exposure of birds to cyanobacterial biomass containing microcystins, acetylcholinesterase inhibitor and anticoagulant.

Ondracek K, Bandouchova H, Damkova V, Hilscherova K, Kral J, Osickova J, Mlcakova V, Pohanka M, Skochova H, Vitula F, Treml F, Pikula J.

Journal Article 2012; 33(Suppl 3): 155-160 PubMed PMID: 23353860  Keywords:  4-Hydroxycoumarins:toxicity, Animals, Anticoagulants:toxicity, Biomass, Brain:drug effects, Carcinogens:toxicity, Cholinesterase Inhibitors:toxicity, Coturnix, Cyanobacteria:chemistry, Female, Heart:drug effects, Kidney:drug effects, Liver:drug effects, L.    Citation

OBJECTIVES: The objective of this study was to examine the hypothesis that a combination of cyanobacterial biomass containing microcystins.....

Read abstract  Full text PDF

Risk of single and combined exposure of birds to non-steroidal anti-inflammatory drugs and lead.

Osickova J, Skochova H, Ondracek K, Kral J, Damkova V, Peckova L, Pohanka M, Vitula F, Bandouchova H, Pikula J.

Journal Article 2012; 33(Suppl 3): 145-150 PubMed PMID: 23353858  Keywords:  Animals, Anti-Inflammatory Agents, Non-Steroidal:toxicity, Blood Proteins:metabolism, Coturnix, Diclofenac:toxicity, Drug Synergism, Environmental Pollutants:toxicity, Gastrointestinal Tract:drug effects, Hemoglobins:metabolism, Lead:toxicity, Lead Poison.    Citation

OBJECTIVES: Pharmaceuticals and heavy metals such as diclofenac and lead, respectively, have been identified as environmental contaminants.....

Read abstract  Full text PDF

Tacrine is implicated in oxidative stress in the laboratory guinea pig model.

Kracmarova A, Bandouchova H, Pikula J, Pohanka M.

Journal Article 2012; 33(Suppl 3): 136-144 PubMed PMID: 23353857  Keywords:  Alzheimer Disease:chemically induced, Animals, Antioxidants:metabolism, Brain:drug effects, Caspase 3:metabolism, Chemical and Drug Induced Liver Injury:metabolism, Cholinesterase Inhibitors:toxicity, Disease Models, Animal, Female, Guinea Pigs, Heart:dru.    Citation

OBJECTIVES: Tacrine was the first acetylcholinesterase inhibitor approved for the treatment of Alzheimer disease. The compound is not avai.....

Read abstract  Full text PDF