Articles by author - Lenka Sedlácková

Chronic unpredictable mild stress paradigm in male Wistar rats: effect on anxiety- and depressive-like behavior.

Koprdova R, Bögi E, Belovičová K, Sedláčková N, Okuliarová M, Ujházy E, Mach M.

Journal Article 2016; 37(Suppl 1): 103-110 PubMed PMID: 28263537  Keywords:  Animals, Anxiety:physiopathology, Behavior, Animal:physiology, Corticosterone:blood, Depression:physiopathology, Disease Models, Animal, Male, Rats, Rats, Wistar, Stress, Psychological:blood,.    Citation

OBJECTIVES: There are several models of depression. Chronic unpredictable mild stress (CMS) appears to have the greatest validity.....

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Psychosocial aspects of resistance in complex treatment of depressive disorder.

Sedlackova Z, Prasko J, Latalova K, Kamaradova D, Ociskova M, Grambal A, Sigmundova Z, Kasalova P, Cakirpaloglu S.

Journal Article 2015; 36(4): 354-362 PubMed PMID: 26454491  Keywords:  Adult, Age Factors, Age of Onset, Antidepressive Agents:therapeutic use, Anxiety:psychology, Cognitive Therapy, Combined Modality Therapy, Depressive Disorder, Major:psychology, Depressive Disorder, Treatment-Resistant:psychology, Female, Humans, Male, Mi.    Citation

OBJECTIVE: Treatment of major depressive disorder can be affected by a broad range of factors. In our study, we focused on the relationshi.....

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Treatment adherence and self-stigma in patients with depressive disorder in remission - A cross-sectional study.

Sedlácková Z, Kamarádová D, Prásko J, Látalová K, Ocisková M, Ocisková M, Cinculová A, Kubínek R, Mainerová B, Tichácková A, Vrbová K.

Journal Article 2015; 36(2): 171-177 PubMed PMID: 26071588  Keywords:  Adult, Age Factors, Age of Onset, Aged, Cross-Sectional Studies, Depressive Disorder:drug therapy, Female, Humans, Male, Medication Adherence:psychology, Middle Aged, Remission Induction, Severity of Illness Index, Social Stigma,.    Citation

OBJECTIVE: A wide range of variables may influence the rate of adherence to treatment. These variables can be associated with the disease .....

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Subchronic perinatal asphyxia increased anxiety-and depression-like behaviors in the rat offspring.

Sedláčková N, Krajčiová M, Koprdová R, Ujházy E, Brucknerová I, Mach M.

Journal Article 2014; 35(Suppl 2): 214-220 PubMed PMID: 25638390  Keywords:  Animals, Anxiety:etiology, Asphyxia:complications, Behavior, Animal:physiology, Depression:etiology, Disease Models, Animal, Female, Pregnancy, Prenatal Exposure Delayed Effects, Rats, Rats, Wistar,.    Citation

OBJECTIVES: Perinatal asphyxia is one of the major cause of mortality in newborns and cause of neurological disorders in adulthood. Brain .....

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Pyridoindole antioxidant-induced preservation of rat hippocampal pyramidal cell number linked with reduction of oxidative stress yet without influence on cognitive deterioration in Alzheimer-like neurodegeneration.

Gasparova Z, Stara V, Janega P, Navarova J, Sedlackova N, Mach M, Ujhazy E.

Journal Article 2014; 35(6): 454-462 PubMed PMID: 25433849  Keywords:  Acetylglucosaminidase:metabolism, Alzheimer Disease:drug therapy, Animals, Antioxidants:pharmacology, CA1 Region, Hippocampal:drug effects, Cognition Disorders:drug therapy, Disease Models, Animal, Indoles:pharmacology, Male, Malondialdehyde:metabolism, M.    Citation

BACKGROUND: The idea of antioxidant therapy attenuating Alzheimer disease (AD) neuropathology starts to be attractive. Animal models are o.....

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