Martinek V, Kubickova B, Arlt V, Frei E, Schmeiser H, Hudecek J, Stiborova M.
Comparative Study 2011; 32(Suppl 1): 57-70 PubMed PMID: 22167209 Keywords: Acetyltransferases:chemistry, Animals, Aristolochic Acids:chemistry, Biotransformation:physiology, Catalytic Domain, Cells, Cultured, DNA Adducts:metabolism, Enzyme Activation, Humans, Lactams:metabolism, Models, Molecular, Molecular Conformation, NAD(P)H. CitationOBJECTIVES: Ingestion of aristolochic acid (AA) is associated with development of urothelial tumors linked with aristolochic acid nephropa.....
Martinek V, Kubickova B, Arlt V, Frei E, Schmeiser H, Hudecek J, Stiborova M. Comparison of activation of aristolochic acid I and II with NADPH:quinone oxidoreductase, sulphotransferases and N-acetyltranferases. Neuro Endocrinol Lett. 2011 Jan; 32(Suppl 1): 57-70
Poljakova J, Hrebackova J, Dvorakova M, Moserova M, Eckschlager T, Hrabeta J, Göttlicherova M, Kopejtkova B, Frei E, Kizek R, Stiborova M.
Journal Article 2011; 32(Suppl 1): 101-116 PubMed PMID: 22167207 Keywords: Animals, Antineoplastic Combined Chemotherapy Protocols:pharmacology, Brain Neoplasms:drug therapy, DNA Damage, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, Ellipticines:administration & dosage, Histone Deacetylase Inhibitors:administra. CitationOBJECTIVES: Valproic acid (VPA) and trichostatin A (TSA) exert antitumor activity as histone deacetylase inhibitors, whereas ellipticine a.....
Poljakova J, Hrebackova J, Dvorakova M, Moserova M, Eckschlager T, Hrabeta J, Göttlicherova M, Kopejtkova B, Frei E, Kizek R, Stiborova M. Anticancer agent ellipticine combined with histone deacetylase inhibitors, valproic acid and trichostatin A, is an effective DNA damage strategy in human neuroblastoma. Neuro Endocrinol Lett. 2011 Jan; 32(Suppl 1): 101-116
Naiman K, Frei E, Stiborova M.
Journal Article 2010; 31(Suppl 2): 36-45 PubMed PMID: 21187827 Keywords: Aniline Compounds:metabolism, Animals, Anisoles:metabolism, Aryl Hydrocarbon Hydroxylases:physiology, Carcinogens:metabolism, Cytochrome P-450 CYP2E1:physiology, Cytochrome P-450 Enzyme System:physiology, Environmental Pollutants:metabolism, Hydroxylamine. CitationOBJECTIVES: N-(2-methoxyphenyl)hydroxylamine is a human metabolite of two industrial and environmental pollutants and bladder carcinogens .....
Naiman K, Frei E, Stiborova M. Identification of rat cytochromes P450 metabolizing N-(2-methoxyphenyl)hydroxylamine, a human metabolite of the environmental pollutants and carcinogens o-anisidine and o-nitroanisole. Neuro Endocrinol Lett. 2010 Jan; 31(Suppl 2): 36-45
Stiborova M, Moserova M, Mrazova B, Kotrbova V, Frei E.
Journal Article 2010; 31(Suppl 2): 26-35 PubMed PMID: 21187821 Keywords: Animals, Antineoplastic Agents:metabolism, Biotransformation:drug effects, Cytochrome P-450 Enzyme System:physiology, DNA Adducts:drug effects, Ellipticines:metabolism, Kidney:metabolism, Liver:metabolism, Lung:metabolism, Male, Microsomes:drug effects, M. CitationOBJECTIVE: Ellipticine is a potent antineoplastic agent exhibiting multiple mechanisms of action. This anticancer agent should be consider.....
Stiborova M, Moserova M, Mrazova B, Kotrbova V, Frei E. Role of cytochromes P450 and peroxidases in metabolism of the anticancer drug ellipticine: additional evidence of their contribution to ellipticine activation in rat liver, lung and kidney. Neuro Endocrinol Lett. 2010 Jan; 31(Suppl 2): 26-35
Vilimkova L, Jechova J, Koubkova Z, Paca J, Kremlackova V, Poljakova J, Paca J, Stiborova M.
Journal Article 2009; 30(Suppl 1): 80-87 PubMed PMID: 20027149 Keywords: Candida tropicalis:enzymology, Catechol 1,2-Dioxygenase:chemistry, Catechols:chemistry, Chromatography, Chromatography, Gel, Chromatography, High Pressure Liquid, Cytosol:chemistry, Dextrans, Dimerization, Electrophoresis, Polyacrylamide Gel, Fungal Prote. CitationOBJECTIVES: Candida tropicalis yeast is a microorganism that possesses high tolerance for phenol and shows strong phenol degrading activit.....
Vilimkova L, Jechova J, Koubkova Z, Paca J, Kremlackova V, Poljakova J, Paca J, Stiborova M. Isolation and partial characterization of catechol 1,2-dioxygenase of phenol degrading yeast Candida tropicalis. Neuro Endocrinol Lett. 2009 Jan; 30(Suppl 1): 80-87
Mrazova B, Martinek V, Martinkova M, Sulc M, Frei E, Stiborova M.
Journal Article 2009; 30(Suppl 1): 72-79 PubMed PMID: 20027148 Keywords: Absorption, Amino Acid Sequence, Animals, Apoproteins:chemistry, Butanones, Chromatography, Cytochromes b5:chemistry, Electrons, Electrophoresis, Polyacrylamide Gel, Heme:chemistry, Horses, Hydrogen-Ion Concentration, Mass Spectrometry, Molecular Sequence. CitationOBJECTIVES: Cytochrome b5 (cyt b5), a component of endoplasmic reticulum membrane, plays a role in modulation of activity of several cytoc.....
Mrazova B, Martinek V, Martinkova M, Sulc M, Frei E, Stiborova M. Preparation of apo-cytochrome b5 utilizing heme transfer to apo-myoglobin. Neuro Endocrinol Lett. 2009 Jan; 30(Suppl 1): 72-79