Indra R, Moserova M, Sulc M, Frei E, Stiborova M.
Comparative Study 2013; 34(Suppl 2): 55-63 PubMed PMID: 24362093 Keywords: Animals, Benzo(a)pyrene:metabolism, Carcinogens:metabolism, Cytochrome P-450 CYP1A1:metabolism, Cytochromes b5:pharmacology, Humans, Inactivation, Metabolic, Male, Microsomes, Liver:drug effects, Oxidation-Reduction, Rats,. CitationOBJECTIVES: Cytochrome P450 (CYP) 1A1 is the most important enzyme in both activation and detoxification of carcinogenic benzo[a]pyrene (B.....
Indra R, Moserova M, Sulc M, Frei E, Stiborova M. Oxidation of carcinogenic benzo[a]pyrene by human and rat cytochrome P450 1A1 and its influencing by cytochrome b5 - a comparative study. Neuro Endocrinol Lett. 2013 Jan; 34(Suppl 2): 55-63
Sulc M, Jecmen T, Snajdrova R, Novak P, Martinek V, Hodek P, Stiborova M, Hudecek J.
Journal Article 2012; 33(Suppl 3): 41-47 PubMed PMID: 23353842 Keywords: Animals, Aryl Hydrocarbon Hydroxylases:chemistry, Carbodiimides:chemistry, Chromatography, Liquid:methods, Cross-Linking Reagents:chemistry, Cytochrome P450 Family 2, Cytochromes b5:chemistry, Dimerization, Electrons, Mass Spectrometry:methods, Microsomes. CitationOBJECTIVES: The cytochrome P450 (P450) and cytochrome b5 are membrane hemoproteins composing together with flavoprotein NADPH:P450 reducta.....
Sulc M, Jecmen T, Snajdrova R, Novak P, Martinek V, Hodek P, Stiborova M, Hudecek J. Mapping of interaction between cytochrome P450 2B4 and cytochrome b5: the first evidence of two mutual orientations. Neuro Endocrinol Lett. 2012 Jan; 33(Suppl 3): 41-47
Mrazova B, Martinek V, Martinkova M, Sulc M, Frei E, Stiborova M.
Journal Article 2009; 30(Suppl 1): 72-79 PubMed PMID: 20027148 Keywords: Absorption, Amino Acid Sequence, Animals, Apoproteins:chemistry, Butanones, Chromatography, Cytochromes b5:chemistry, Electrons, Electrophoresis, Polyacrylamide Gel, Heme:chemistry, Horses, Hydrogen-Ion Concentration, Mass Spectrometry, Molecular Sequence. CitationOBJECTIVES: Cytochrome b5 (cyt b5), a component of endoplasmic reticulum membrane, plays a role in modulation of activity of several cytoc.....
Mrazova B, Martinek V, Martinkova M, Sulc M, Frei E, Stiborova M. Preparation of apo-cytochrome b5 utilizing heme transfer to apo-myoglobin. Neuro Endocrinol Lett. 2009 Jan; 30(Suppl 1): 72-79
Hodek P, Tepla M, Krizkova J, Sulc M, Stiborova M.
Journal Article 2009; 30(Suppl 1): 67-71 PubMed PMID: 20027147 Keywords: Animals, Antioxidants:pharmacology, Benzoflavones:chemistry, Carbon Monoxide:metabolism, Cytochrome P-450 Enzyme System:metabolism, Cytochromes b5:metabolism, Cytochromes c:metabolism, Ferricyanides:metabolism, Flavonoids:chemistry, Fluorometry, Male, Mic. CitationOBJECTIVES: The aim of this study was to assess the effect of various flavonoids on the NADPH:cytochrome P450 oxidoreductase (CYPOR) activ.....
Hodek P, Tepla M, Krizkova J, Sulc M, Stiborova M. Modulation of cytochrome P450 enzyme system by selected flavonoids. Neuro Endocrinol Lett. 2009 Jan; 30(Suppl 1): 67-71
Sulc M, Hudecek J, Stiborova M, Hodek P.
Journal Article 2008; 29(5): 722-727 PubMed PMID: 18987581 Keywords: Adamantane:analogs & derivatives, Amino Acid Sequence, Animals, Arginine:genetics, Aryl Hydrocarbon Hydroxylases:antagonists & inhibitors, Chromatography, High Pressure Liquid, Crystallography, X-Ray, Cytochrome P450 Family 2, Enzyme Inhibitors:pharmacolo. CitationOBJECTIVES: Understanding the enzyme mechanism of P450 enzymes needs a detailed knowledge of substrate-enzyme interactions. Here, we exami.....
Sulc M, Hudecek J, Stiborova M, Hodek P. Structural analysis of binding of a diamantoid substrate to cytochrome P450 2B4: possible role of Arg 133 in modulation of function and activity of this enzyme. Neuro Endocrinol Lett. 2008 Oct; 29(5): 722-727