Bureš J, Jun D, Hrabinová M, Tachecí I, Květina J, Pavlík M, Rejchrt S, Douda T, Kuneš M, Kuča K, Kopáčová M.
Journal Article 2015; 36(Suppl 1): 150-155 PubMed PMID: 26757120 Keywords: Animals, Cholinesterase Inhibitors:pharmacology, Electromyography, Female, Muscle, Smooth:drug effects, Stomach:drug effects, Sus scrofa, Tacrine:analogs & derivatives,. CitationOBJECTIVES: Tacrine was the first acetylcholinesterase inhibitor approved for therapy of Alzheimer's disease. It has currently been withdr.....
Bureš J, Jun D, Hrabinová M, Tachecí I, Květina J, Pavlík M, Rejchrt S, Douda T, Kuneš M, Kuča K, Kopáčová M. Impact of tacrine and 7-methoxytacrine on gastric myoelectrical activity assessed using electrogastrography in experimental pigs. Neuro Endocrinol Lett. 2015 Jan; 36(Suppl 1): 150-155
Kuneš M, Květina J, Bureš J, Karasová J, Pavlík M, Tachecí I, Musílek K, Kuca K.
Journal Article 2014; 35(Suppl 2): 191-196 PubMed PMID: 25638385 Keywords: Animals, Cholinesterase Reactivators:administration & dosage, Female, Oximes:administration & dosage, Pyridinium Compounds:administration & dosage, Sus scrofa:blood, Tissue Distribution,. CitationOBJECTIVES: Oxime HI-6 DMS (dimethanesulfonate) is an asymmetric bis-pyridinium aldoxime and essential acetylcholinesterase (AChE.....
Kuneš M, Květina J, Bureš J, Karasová J, Pavlík M, Tachecí I, Musílek K, Kuca K. HI-6 oxime (an acetylcholinesterase reactivator): blood plasma pharmacokinetics and organ distribution in experimental pigs. Neuro Endocrinol Lett. 2014 Jan; 35(Suppl 2): 191-196
Bures J, Kvetina J, Pavlik M, Kunes M, Kopacova M, Rejchrt S, Jun D, Hrabinova M, Kuca K, Tachecí I.
Journal Article 2013; 34(Suppl 2): 79-83 PubMed PMID: 24362097 Keywords: Animals, Cholinesterase Reactivators:administration & dosage, Electromyography, Female, Heart Rate:drug effects, Injections, Intramuscular, Models, Animal, Oximes:administration & dosage, Paraoxon:administration & dosage, Pyridinium Compounds:administrati. CitationOBJECTIVES: Organophosphorus compounds represent nerve agents, pesticides and several industrial compounds. Treatment after exposure to or.....
Bures J, Kvetina J, Pavlik M, Kunes M, Kopacova M, Rejchrt S, Jun D, Hrabinova M, Kuca K, Tachecí I. Impact of paraoxon followed by acetylcholinesterase reactivator HI-6 on gastric myoelectric activity in experimental pigs. Neuro Endocrinol Lett. 2013 Jan; 34(Suppl 2): 79-83
Zdarova Karasova J, Zemek F, Kunes M, Kvetina J, Chladek J, Jun D, Bures J, Tachecí I, Kuca K.
Comparative Study 2013; 34(Suppl 2): 74-78 PubMed PMID: 24362096 Keywords: Absorption, Animals, Biological Availability, Chlorides:administration & dosage, Cholinesterase Reactivators:administration & dosage, Female, Injections, Intramuscular, Injections, Intravenous, Oximes:administration & dosage, Pyridinium Compounds:administ. CitationOBJECTIVES: Oxime HI-6 is an acetylcholinesterase reactivator therapeutically efficient against nerve agents. Because of their physico-che.....
Zdarova Karasova J, Zemek F, Kunes M, Kvetina J, Chladek J, Jun D, Bures J, Tachecí I, Kuca K. Intravenous application of HI-6 salts (dichloride and dimethansulphonate) in pigs: comparison with pharmacokinetics profile after intramuscular administration. Neuro Endocrinol Lett. 2013 Jan; 34(Suppl 2): 74-78
Tachecí I, Kvetina J, Kunes M, Edakkanambeth Varayil J, Ali S, Pavlik M, Kopacova M, Rejchrt S, Bures J, Pleskot M.
Journal Article 2011; 32(Suppl 1): 131-136 PubMed PMID: 22167215 Keywords: Animals, Dextran Sulfate, Drug Evaluation, Preclinical, Electromyography:methods, Electrophysiological Phenomena:drug effects, Erythromycin:administration & dosage, Female, Gastrointestinal Agents:administration & dosage, Gastrointestinal Diseases:chemica. CitationOBJECTIVES: Electrogastrography (EGG) is a non-invasive investigation of gastric myoelectrical activity. The aim of study was to evaluate .....
Tachecí I, Kvetina J, Kunes M, Edakkanambeth Varayil J, Ali S, Pavlik M, Kopacova M, Rejchrt S, Bures J, Pleskot M. Electrogastrography in experimental pigs: the influence of gastrointestinal injury induced by dextran sodium sulphate on porcine gastric erythromycin-stimulated myoelectric activity. Neuro Endocrinol Lett. 2011 Jan; 32(Suppl 1): 131-136
Kvetina J, Kunes M, Bures J, Kopacova M, Tachecí I, Spelda S, Herout V, Rejchrt S.
Journal Article 2008; 29(5): 763-769 PubMed PMID: 18987574 Keywords: Animals, Anti-Inflammatory Agents, Non-Steroidal:toxicity, Capsule Endoscopy:methods, Female, Gastric Mucosa:pathology, Gastroscopy, Indomethacin:toxicity, Intestinal Mucosa:pathology, Microscopy, Confocal, Peptic Ulcer:chemically induced, Swine,. CitationOBJECTIVES: The aim was the utilization of capsule microscopy and other diagnostic techniques for prospective pre-clinical research of abs.....
Kvetina J, Kunes M, Bures J, Kopacova M, Tachecí I, Spelda S, Herout V, Rejchrt S. The use of wireless capsule enteroscopy in a preclinical study: a novel diagnostic tool for indomethacin-induced gastrointestinal injury in experimental pigs. Neuro Endocrinol Lett. 2008 Oct; 29(5): 763-769