Articles by author - Hiroyuki Umegaki

The response of the autonomic nervous system to the cholinesterase inhibitor, donepezil.

Umegaki H, Khookhor O.

Journal Article 2013; 34(5): 383-387 PubMed PMID: 23922048  Keywords:  Animals, Autonomic Nervous System:drug effects, Cholinesterase Inhibitors:pharmacology, Heart Rate:drug effects, Indans:pharmacology, Male, Piperidines:pharmacology, Rats, Rats, Wistar,.    Citation

OBJECTIVE: Donepezil, a cholinesterase inhibitor (ChEI) that is widely used to treat Alzheimer's disease, is thought to act by increasing .....

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The cholinergic stimulation of the hippocampus induced the activation of the sympathetic nervous system.

Khookhor O, Umegaki H.

Journal Article 2013; 34(1): 58-61 PubMed PMID: 23524625  Keywords:  Animals, Cholinergic Neurons:drug effects, Cholinesterase Inhibitors:pharmacology, Heart Rate:drug effects, Hippocampus:cytology, Hypothalamo-Hypophyseal System:cytology, Male, Microinjections, Neostigmine:pharmacology, Pituitary-Adrenal System:cytology, .    Citation

OBJECTIVES: We previously demonstrated that the direct microinjection of cholinesterase inhibitor (neostigmine) into the hippocampus in ra.....

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Different contribution of the lateral bed nucleus of the stria terminalis in intrahippocampal neostigmine-induced elevation of plasma glucose and adrenocorticotropic hormone in free moving rats.

Zhu W, Cui J, Wang W, Zhang R, Umegaki H.

Journal Article 2009; 30(4): 511-514 PubMed PMID: 20010499  Keywords:  Adrenocorticotropic Hormone:blood, Animals, Blood Glucose:drug effects, Cholinergic Fibers:drug effects, Cholinesterase Inhibitors:pharmacology, Hippocampus:cytology, Male, Microinjections, Motor Activity, Neostigmine:pharmacology, Neural Pathways, Rats, .    Citation

OBJECTIVE: In our previous study, a lesion in the lateral bed nucleus of the stria terminalis (BNSTL) was found to significantly attenuate.....

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Effect of the entorhinal cortex on diurnal ACTH and corticosterone release in rats.

Zhu W, Zhang R, Hu C, Umegaki H.

Journal Article 2008; 29(1): 159-162 PubMed PMID: 18283263  Keywords:  Adrenocorticotropic Hormone:blood, Animals, Body Weight:physiology, Central Nervous System:physiology, Circadian Rhythm:physiology, Corticosterone:blood, Entorhinal Cortex:physiology, Hypothalamo-Hypophyseal System:physiology, Male, Pituitary-Adrenal Syst.    Citation

OBJECTIVE: In our previous study, a lesion in the entorhinal cortex was found to significantly attenuate the elevation of adrenocorticotro.....

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Stimulation of the hippocampal glutamate receptor systems induces stress-like responses.

Umegaki H, Yamamoto A, Suzuki Y, Iguchi A.

Comparative Study 2006; 27(3): 339-343 PubMed PMID: 16807523  Keywords:  Acetylcholine:metabolism, Adrenocorticotropic Hormone:blood, Analysis of Variance, Animals, Behavior, Animal:drug effects, Blood Glucose:metabolism, Cholinesterase Inhibitors:administration & dosage, Dose-Response Relationship, Drug, Excitatory Amino Acid.    Citation

OBJECTIVE: The hypothalamic-pituitary-adrenal (HPA) axis controls glucocorticoid secretion and is in turn controlled by a diverse set of a.....

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Microdialysis measurement of acetylcholine in rat hippocampus during severe insulin-induced hypoglycemia.

Umegaki H, Yamaguchi Y, Suzuki Y, Iguchi A.

Journal Article 2006; 27(1-2): 128-132 PubMed PMID: 16648788  Keywords:  Acetylcholine:metabolism, Animals, Blood Glucose:metabolism, Hippocampus:metabolism, Hypoglycemia:chemically induced, Hypoglycemic Agents, Insulin, Male, Microdialysis, Neostriatum:drug effects, Rats, Rats, Wistar,.    Citation

OBJECTIVE: It has been well acknowledged that hypoglycemia induces cognitive impairment. However, the behavior of hippocampal cholinergic .....

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