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Case Reports 2007; 28(6): 734-738 PubMed PMID: 18063929 Citation  Keywords:  Aorta, Abdominal:abnormalities, Aortic Diseases:complications, Child, Child, Preschool, Constriction, Pathologic, Female, Glioma:complications, Humans, Hypertension, Renovascular:complications, Hypertrophy, Left Ventricular:complications, Mutation, Neurof.   

OBJECTIVES: Neurofibromatosis von Recklinghausen type 1 (NF1) is an autosomal dominant neurocutaneous disorder affecting one in 3 000-4 000 individuals. Mid-aortic syndrome (MAS) is a rare condition characterized by segmental narrowing of abdominal aorta and stenosis of its major branches - mainly renal arteries, including manifestation of renovascular hypertension. MAS can be caused by different diseases, including NF1.r />r /> MAIN FINDINGS: A 9 years old girl with primary diagnosis of NF1 combined with renovascular hypertension due to MAS, suffered of bilateral optic and chiasm glioma, pubertas praecox, speech disorder, light mental retardation and scoliosis. We have found a mutation in exone 34 of the NF1 gene (17q11.2). Her father has been also diagnosed with NF1 and hypertension developed at early age. He has the same mutation in exone 34 of NF1 gene. The girl is currently treated with conservative antihypertensive medication with positive effect. Bilateral optic and chiasm glioma are asymptomatic at the time and they had been without progress over period of time. Any vascular surgery, neurosurgical and oncological therapy are not indicated at the present time.r />r /> CONCLUSION: This article is a summary of clinical findings in patient with NF1 due to NF1 gene mutation in exone 34. It confirms the importance of complex multidisciplinar approach to examination and taking care of NF1 patients and their families....

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Case Reports 2007; 28(6): 739-744 PubMed PMID: 18063928 Citation  Keywords:  Adolescent, Antibodies:blood, Antioxidants:therapeutic use, Biomarkers, Diet Therapy, Enterobacteriaceae:immunology, Enterobacteriaceae Infections:complications, Fatigue Syndrome, Chronic:etiology, Female, Humans, Immunoglobulins, Intravenous:therapeutic .   

: There is now evidence that chronic fatigue syndrome (CFS) is accompanied by an increased translocation of endotoxins from gram-negative enterobacteria through the gut wall, as demonstrated by increased prevalences and median values for serum IgM and IgA against the endotoxins of gram-negative enterobacteria. This condition can also be described as increased gut permeability or leaky gut and indicates intestinal mucosal dysfunction (IMD). Here we report a case of a 13 year old girl with CFS who showed very high values for serum IgM against the LPS of some enterobacteria and signs of oxidative and nitrosative stress, activation of the inflammatory response system, and IgG3 subclass deficiency. Upon treatment with specific antioxidants and a "leaky gut diet", which both aim to treat increased gut permeability, and immunoglobins intravenously, the increased translocation of the LPS of gram negative enterobacteria normalized and this normalization was accompanied by a complete remission of the CFS symptoms....

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Comparative Study 2007; 28(6): 901-907 PubMed PMID: 18063927 Citation  Keywords:  Adiponectin:blood, Adult, Cholesterol:blood, Diabetes Mellitus, Type 2:blood, Energy Metabolism:physiology, European Continental Ancestry Group, Female, Humans, Male, Matched-Pair Analysis, Middle Aged, Obesity:blood, Statistics, Nonparametric, Triglyceri.   

OBJECTIVES: Adiponectin is a novel plasma protein produced exclusively in adipocytes. Despite early data, its relationship with obesity and diabetes has been recently questioned. Since plasma lipids influence diabetes and obesity, of concern is whether any associations between plasma lipids and adiponectin exist.r />r /> DESIGN AND METHODS: The aim of this study was to measure adiponectin levels and to investigate their associations with plasma cholesterol fractions and triglycerides in 73 obese non-diabetic subjects (44 women and 29 men), and 43 obese diabetic subjects (28 women and 15 men), aged 52.7+/-11.2 and 53.1+/-11 years, respectively, and matched for age, sex and BMI. The WHO definitions of obesity and diabetes were used. Adiponectin was determined by an enzyme-linked immunosorbent assay.r />r /> RESULTS: No correlations between adiponectin and total and LDL cholesterol levels were shown (for the whole cohort: r=0.0130; p=0.8899, and r=0.0807; p=0.3958, respectively). A positive correlation between HDL cholesterol levels and adiponectin occured predominantly in obese women without diabetes (r=0.4531; p=0.0023), resulting in an overall statistical trend in the whole cohort (r=0.2243; p=0.0164). A negative correlation between serum adiponectin and triglycerides was found (r=-0.3413; p=0.0002).r />r /> CONCLUSION: Adiponectin correlated only with TG and partially with HDL but not with LDL and total cholesterol in the study group of obese diabetic and obese non diabetic subjects. In view of these results we suggest that the role of adiponectin in human metabolism is unclear and merits further investigation....

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Historical Article 2007; 28(6): 749-756 PubMed PMID: 18063926 Citation  Keywords:  Behavior:radiation effects, Cultural Characteristics, Dissent and Disputes:history, Electromagnetic Fields, History, History, 15th Century, History, 16th Century, History, 17th Century, History, 18th Century, History, 19th Century, History, 20th Century, .   

BACKGROUND: Russian astronomer A.L. Tchijevsky published in the twenties of 20th century a study comparing the approximately 11-year cycling of "sunspot activity" and "historical process", analyzed globally since the 5th century B.C. to the 19th century A.D. According to him, phenomena of societal "excitation", as revolutions, occurred synchronously with the solar maxima, and, oppositely, those of peaceful activities of masses, as science and arts, with the solar minima. Recently, Slovak philosopher E. Páles describes periodic fluctuation of historical events in mutually distant geographic areas during more than three millennia. The period lengths, however, are longer, one of the most pronounced being around 500 years. THE QUESTION was therefore posed: does a similar correlation with sunspot activity, as found for 11-year cycles, exist also in the 500-year cycling?r />r /> MATERIAL AND METHODS: The historical data consisted of two time series concerning revolutions in Europe and China, and of eight time series from activities in science and arts registered from five geographic areas. For the comparison, parallel time series of sunspot (Wolf) numbers, available since IInd century B.C., were constructed. Using periodic regression function, the times of peaking were estimated for each data set.r />r /> RESULTS: In agreement with Tchijevsky's hypothesis, revolutions culminated near to solar maxima while cultural flourishing usually distinctly near to solar minima. This conclusion is based on the level of statistical significance alpha=0.05.r />r /> CONCLUSION: Solar impact on geomagnetic field could be one of elucidating mechanisms. Recently, electromagnetic influencing of brain function has been realized artificially....

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Journal Article 2007; 28(6): 811-814 PubMed PMID: 18063925 Citation  Keywords:  Adult, Antipsychotic Agents:therapeutic use, Humans, Male, Psychiatric Status Rating Scales, Risperidone:therapeutic use, Schizophrenia:blood, Schizophrenic Psychology, Severity of Illness Index, Statistics, Nonparametric, Testosterone:blood,.   

OBJECTIVE: Recent neuroendocrinological studies have suggested that gonadal sex hormones play a significant role in the pathophysiology of schizophrenia. Low testosterone is associated with negative symptoms in chronic schizophrenia. The relevance of these findings has not yet been elucidated. The aim of our naturalistic open study was to explore the association between symptoms, drug response and testosterone levels in first-episode schizophrenia to exclude the effects of age, chronic illness, long-term treatment and institutionalization.r />r /> METHODS: 68 males, consecutively hospitalised for the first time with first-episode schizophrenia were evaluated using the Positive and Negative Syndrome Scale (PANSS) on admission (before treatment) and at discharge. Further, plasma testosterone was measured. Total testosterone was assayed using chemiluminescent immunoanalysis (CMIA). All patients were treated openly by monotherapy; risperidone being the drug of first choice. Treatment response was defined as delta PANSS (PANSS total on admission - PANSS total at discharge /PANSS total on admission).r />r /> RESULTS: On average the total PANSS and PANSS subscales scores significantly decreased during the acute treatment. In contrast to results in chronic schizophrenia, the mean values of testosterone were within the normal range (15.36 and 22.55 nmol/l respectively) both before and after acute treatment. The range of normal values for the method used is given as 5.76-30.43 nmol/l for males <50 years old. On admission only 6 patients had testosterone values lower than 5.76 nmol/l. No significant correlation between negative symptoms (negative PANSS subscale) at the beginning or at the end of acute treatment or between treatment response and testosterone plasma levels was found.r />r /> CONCLUSIONS: During the first psychotic breakdown no significant association was observed either between total testosterone plasma levels and symptoms or treatment reactivity. However, schizophrenia is a heterogeneous disease. In some patients with first-episode schizophrenia an alteration of psychoendocrinology parameters has been observed. These patients may be more vulnerable to development of enduring negative symptoms, and pharmacotherapy based on neuroendocrinology profile should be considered....

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Journal Article 2007; 28(6): 895-900 PubMed PMID: 18063924 Citation  Keywords:  Adolescent, Adult, Age Factors, Autistic Disorder:classification, Child, Child, Preschool, Diagnostic Errors:statistics & numerical data, Early Diagnosis, Early Intervention (Education):standards, Female, Humans, Infant, Male, Parents, Quality of Health C.   

: The primary aim of the research was to find the delay between the first symptoms of an autistic disorder being recognized by parents and diagnosis in our centre. A secondary objective was to evaluate the number of contacts with professionals (physicians, teachers, and speech therapists) in which parents pointed out special manifestations seen in children and, in spite of that, the children were not referred to a specialist. A retrospective study assessed 204 children (59 girls, 145 boys) in total; 126 children (39 girls, 87 boys) with childhood autism (CHA), 57 (17 girls, 40 boys) with atypical autism (AA), and 21 (3 girls, 18 boys) with Asperger's syndrome (AS). The mean age at appearance of the first signs was 29.7 months (range 0-70, median 30+/-17.0) in N=201, and the average age at diagnosis was 81.5 months (range 13-276, median 69.5+/-45.2) in N=204. The mean delay in making a diagnosis was 51.3 months (range 0-246, median 39+/-40.9) in N=201. The delay in diagnosis is shortest in patients with AA (a mean period of 44.4 months = 3 years and 8 months), longer in CHA patients (49.5 months = 4 years and 2 months), and longest in patients with AS (80.8 months = 6 years and 9 months). A statistically significant difference in the period to diagnosis was found between CHA and AS patients (p=0.023) and between AA and AS patients (p=0.019). The mean number of visits to physicians and other specialists before referring to a specialized centre for diagnosis in N=133 was 2.4 (range 1-5, median 2+/-0.9). The diagnosis of autism is made late and early educational and behavioural interventions cannot be initiated....

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Journal Article 2007; 28(6): 826-831 PubMed PMID: 18063923 Citation  Keywords:  Adult, Anti-Inflammatory Agents:immunology, Cytokines:immunology, Depressive Disorder:metabolism, Female, Gene Expression Regulation:immunology, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase:immunology, Inflammation:metabolism, Interferon-gamma:immunology,.   

: Immune activation is accompanied by induction of indoleamine (2,3)-dioxygenase (IDO), an enzyme which degrades tryptophan, a phenomenon which plays a role in the pathophysiology of major depression and post-natal depression and anxiety states. TRYCATs - tryptophan catabolites along the IDO pathway - such as kynurenine, kynurenic acid, xanthurenic acid, and quinolinic acid, have multiple effects, e.g. apoptotic, anti- versus pro-oxidant, neurotoxic versus neuroprotective, and anxiolytic versus anxiogenic effects. The aim of the present study was to study the immune effects of the above TRYCATS. Toward this end we examined the effects of the above TRYCATs on the LPS + PHA-induced production of interferon-gamma (IFNgamma), interleukin-10 (IL-10), and tumor necrosis factor-alpha (TNFalpha) in 18 normal volunteers. We found that the production of IFNgamma was significantly decreased by all 4 catabolites. Xanthurenic acid and quinolinic acid decreased the production of IL-10. Kynurenine, kynurenic acid, and xanthurenic acid, decreased the IFNgamma/IL-10 production ratio, whereas quinolinic acid increased this ratio. Kynurenic acid significantly reduced the stimulated production of TNFalpha. It is concluded that kynurenine, kynurenic acid, and xanthurenic acid have anti-inflammatory effects trough a reduction of IFNgamma, whereas quinolinic acid has pro-inflammatory effects in particular via significant decreases in IL-10. Following inflammation-induced IDO activation, some TRYCATs, i.e. kynurenine, kynurenic acid, and xanthurenic acid, exert a negative feedback control over IFNgamma production thus downregulating the initial inflammation, whereas an excess of quinolinic acid further aggravates the initial inflammation....

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Journal Article 2007; 28(6): 832-840 PubMed PMID: 18063922 Citation  Keywords:  Autonomic Nervous System:physiopathology, Cardiovascular Diseases:complications, Depressive Disorder:complications, Humans, Hypothalamo-Hypophyseal System:physiopathology, Inflammation:complications, Pituitary-Adrenal System:physiopathology, Psychology,.   

: Depressive disorders and cardiovascular disease are inter-connected by a whole range of pathophysiological mechanisms. Three biological mechanisms are fundamental: activation of the hypothalamus-hypohysis-adrenal axis with a subsequent increase in sympathetic-adrenal system activity, decrease in vagal tone with a decrease in heart rate variability, and alterations of thrombogenesis with increased platelet aggregability. Behavioural mechanisms and psycho-social factors are also integral to this common pathophysiology. Recently, research has focused mainly on studying various forms of stress, as well as changes and possibilities of influencing the autonomous vegetative system. Temporal aspects of the incidence and development of depressive episodes in relation to cardiovascular disease and subsequent cardiovascular morbidity and mortality are being studied, as well as general mortality risk factors. These findings are important for clinical practice. It is evident that in patients with untreated depressive disorder, the risk of developing cardiovascular disease is significantly higher than in patients suffering from a depressive disorder being treated with anti-depressants. From the data published so far, it may be surmised that depressive disorders in patients with cardiovascular disease may be reliably and safely treated with anti-depressants that act as inhibitors of serotonin re-uptake....

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